Literature DB >> 2461264

An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells.

S Seki1, T Oda.   

Abstract

A protein factor having exonucleolytic activity on bleomycin-damaged DNA and providing priming sites for DNA polymerases existed in a DNA polymerase beta fraction partially purified by ion exchange chromatography from an extract of permeable mouse ascites sarcoma (SR-C3H/He) cells. The exonuclease was separated from DNA polymerase beta by single-stranded DNA-cellulose chromatography, and partially characterized. The enzyme is suggested to be involved in the initial step of repair of bleomycin-damaged DNA in removing 3' ends (3'-phosphoglycolate termini) of bleomycin-damaged DNA.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2461264     DOI： 10.1093/carcin/9.12.2239

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  5 in total

1.  Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA.

Authors:  T A Winters; M Weinfeld; T J Jorgensen
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

2.  In situ activity gel for DNA repair 3'-phosphodiesterase.

Authors:  M Sander
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

3.  Isolation of cDNA clones encoding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: homology with bacterial repair enzymes.

Authors:  C N Robson; A M Milne; D J Pappin; I D Hickson
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

4.  Repair of DNA damaged by UV light and ionizing radiation by cell-free extracts prepared from Schizosaccharomyces pombe.

Authors:  K Sidik; H B Lieberman; G A Freyer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

5.  Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines.

Authors:  Y Ono; K Matsumoto; T Furuta; T Ohmoto; K Akiyama; S Seki
Journal:  J Neurooncol       Date:  1995       Impact factor: 4.130
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.