Literature DB >> 24612452

Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3.

P Singh1, A Benjak, S Carat, M Kai, P Busso, C Avanzi, A Paniz-Mondolfi, C Peter, K Harshman, J Rougemont, M Matsuoka, S T Cole.   

Abstract

Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M. leprae.
© 2014 The Authors Clinical Microbiology and Infection © 2014 European Society of Clinical Microbiology and Infectious Diseases.

Entities:  

Keywords:  Leprosy; Mycobacterium leprae; molecular epidemiology; rifampicin-resistance; single nucleotide polymorphism

Mesh：

Year:  2014        PMID： 24612452     DOI： 10.1111/1469-0691.12609

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  8 in total

1.  Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.

Authors:  Camilo Beltrán-Alzate; Fernando López Díaz; Marcela Romero-Montoya; Rama Sakamuri; Wei Li; Miyako Kimura; Patrick Brennan; Nora Cardona-Castro
Journal:  PLoS Negl Trop Dis       Date:  2016-10-05

2.  Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.

Authors:  Andrej Benjak; Charlotte Avanzi; Pushpendra Singh; Chloé Loiseau; Selfu Girma; Philippe Busso; Amanda N Brum Fontes; Yuji Miyamoto; Masako Namisato; Kidist Bobosha; Claudio G Salgado; Moisés B da Silva; Raquel C Bouth; Marco A C Frade; Fred Bernardes Filho; Josafá G Barreto; José A C Nery; Samira Bührer-Sékula; Andréanne Lupien; Abdul R Al-Samie; Yasin Al-Qubati; Abdul S Alkubati; Gisela Bretzel; Lucio Vera-Cabrera; Fatoumata Sakho; Christian R Johnson; Mamoudou Kodio; Abdoulaye Fomba; Samba O Sow; Moussa Gado; Ousmane Konaté; Mariane M A Stefani; Gerson O Penna; Philip N Suffys; Euzenir Nunes Sarno; Milton O Moraes; Patricia S Rosa; Ida M F Dias Baptista; John S Spencer; Abraham Aseffa; Masanori Matsuoka; Masanori Kai; Stewart T Cole
Journal:  Nat Commun       Date:  2018-01-24       Impact factor: 14.919

3.  Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros.

Authors:  Charlotte Avanzi; Emmanuel Lécorché; Fetra Angelot Rakotomalala; Andrej Benjak; Fahafahantsoa Rapelanoro Rabenja; Lala S Ramarozatovo; Bertrand Cauchoix; Mala Rakoto-Andrianarivelo; Maria Tió-Coma; Thyago Leal-Calvo; Philippe Busso; Stefanie Boy-Röttger; Aurélie Chauffour; Tahinamandrato Rasamoelina; Aina Andrianarison; Fandresena Sendrasoa; John S Spencer; Pushpendra Singh; Digambar Ramchandra Dashatwar; Rahul Narang; Jean-Luc Berland; Vincent Jarlier; Claudio G Salgado; Milton O Moraes; Annemieke Geluk; Andriamira Randrianantoandro; Emmanuelle Cambau; Stewart T Cole
Journal:  Front Microbiol       Date:  2020-05-11       Impact factor: 5.640

4.  Emergence and Transmission of Drug-/Multidrug-resistant Mycobacterium leprae in a Former Leprosy Colony in the Brazilian Amazon.

Authors:  Patrícia S Rosa; Helena R S D'Espindula; Ana C L Melo; Amanda N B Fontes; Amanda J Finardi; Andréa F F Belone; Beatriz G C Sartori; Carla A A Pires; Cleverson T Soares; Flávio B Marques; Francisco J D Branco; Ida M F D Baptista; Lázara M Trino; Luciana R V Fachin; Marília B Xavier; Marcos C Floriano; Somei Ura; Suzana M Diório; Wladimir F B Delanina; Milton O Moraes; Marcos C L Virmond; Philip N Suffys; Marcelo T Mira
Journal:  Clin Infect Dis       Date:  2020-05-06       Impact factor: 9.079

5.  Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes.

Authors:  Saskia Pfrengle; Judith Neukamm; Christiana L Scheib; Sarah A Inskip; Verena J Schuenemann; Meriam Guellil; Marcel Keller; Martyna Molak; Charlotte Avanzi; Alena Kushniarevich; Núria Montes; Gunnar U Neumann; Ella Reiter; Rezeda I Tukhbatova; Nataliya Y Berezina; Alexandra P Buzhilova; Dmitry S Korobov; Stian Suppersberger Hamre; Vitor M J Matos; Maria T Ferreira; Laura González-Garrido; Sofia N Wasterlain; Célia Lopes; Ana Luisa Santos; Nathalie Antunes-Ferreira; Vitória Duarte; Ana Maria Silva; Linda Melo; Natasa Sarkic; Lehti Saag; Kristiina Tambets; Philippe Busso; Stewart T Cole; Alexei Avlasovich; Charlotte A Roberts; Alison Sheridan; Craig Cessford; John Robb; Johannes Krause
Journal:  BMC Biol       Date:  2021-10-05       Impact factor: 7.431

6.  Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.

Authors:  Verena J Schuenemann; Charlotte Avanzi; Ben Krause-Kyora; Alexander Seitz; Alexander Herbig; Sarah Inskip; Marion Bonazzi; Ella Reiter; Christian Urban; Dorthe Dangvard Pedersen; G Michael Taylor; Pushpendra Singh; Graham R Stewart; Petr Velemínský; Jakub Likovsky; Antónia Marcsik; Erika Molnár; György Pálfi; Valentina Mariotti; Alessandro Riga; M Giovanna Belcastro; Jesper L Boldsen; Almut Nebel; Simon Mays; Helen D Donoghue; Sonia Zakrzewski; Andrej Benjak; Kay Nieselt; Stewart T Cole; Johannes Krause
Journal:  PLoS Pathog       Date:  2018-05-10       Impact factor: 6.823

7.  2000-year-old pathogen genomes reconstructed from metagenomic analysis of Egyptian mummified individuals.

Authors:  Judith Neukamm; Saskia Pfrengle; Martyna Molak; Alexander Seitz; Michael Francken; Partick Eppenberger; Charlotte Avanzi; Ella Reiter; Christian Urban; Beatrix Welte; Philipp W Stockhammer; Barbara Teßmann; Alexander Herbig; Katerina Harvati; Kay Nieselt; Johannes Krause; Verena J Schuenemann
Journal:  BMC Biol       Date:  2020-08-28       Impact factor: 7.431

8.  Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus.

Authors:  Anna K Fotakis; Sean D Denham; Meaghan Mackie; Miren Iraeta Orbegozo; Dorothea Mylopotamitaki; Shyam Gopalakrishnan; Thomas Sicheritz-Pontén; Jesper V Olsen; Enrico Cappellini; Guojie Zhang; Axel Christophersen; M Thomas P Gilbert; Åshild J Vågene
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-10-05       Impact factor: 6.237
  8 in total

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