Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Total synthesis of nucleoside antibiotic A201A.

Literature DB >> 24611434

Total synthesis of nucleoside antibiotic A201A.

Abstract

A201A, a unique nucleoside antibiotic with potent antibacterial activities, has been synthesized for the first time in a total of 47 steps in a highly modular and linear manner, highlighting the elaboration/incorporation of an unprecedented hexofuranoside unit bearing an exocyclic enol ether moiety.

Entities: Chemical

Mesh：

Substances：
Aminoglycosides
A 201A

Year: 2014 PMID： 24611434 DOI： 10.1021/ja501460j

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

10 in total

1. Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus.

Authors: Irene Saugar; Brian Molloy; Eloisa Sanz; María Blanca Sánchez; María Fernández-Lobato; Antonio Jiménez
Journal: J Antibiot (Tokyo) Date: 2016-10-12 Impact factor: 2.649

2. Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Authors: Yury S Polikanov; Agata L Starosta; Manuel F Juette; Roger B Altman; Daniel S Terry; Wanli Lu; Benjamin J Burnett; George Dinos; Kevin A Reynolds; Scott C Blanchard; Thomas A Steitz; Daniel N Wilson
Journal: Mol Cell Date: 2015-05-28 Impact factor: 17.970

3. Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase.

Authors: Qinghua Zhu; Qi Chen; Yongxiang Song; Hongbo Huang; Jun Li; Junying Ma; Qinglian Li; Jianhua Ju
Journal: Proc Natl Acad Sci U S A Date: 2017-04-24 Impact factor: 11.205

Total synthesis of nucleoside antibiotic A201A.

1. Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus.

2. Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

3. Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase.

Review 4. Direct Dehydrative Glycosylation of C1-Alcohols.

5. Total Synthesis of (-)-Spinosyn A via Carbonylative Macrolactonization.

6. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects.

7. Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

8. A versatile glycosylation strategy via Au(iii) catalyzed activation of thioglycoside donors.

Review 9. Engineering nucleoside antibiotics toward the development of novel antimicrobial agents.

Review 10. Anomeric modification of carbohydrates using the Mitsunobu reaction.