| Literature DB >> 24610685 |
Mohammad Mahdi Hasani-Sadrabadi1, Vahid Karimkhani, Fatemeh Sadat Majedi, Jules John Van Dersarl, Erfan Dashtimoghadam, Faramarz Afshar-Taromi, Hamid Mirzadeh, Arnaud Bertsch, Karl I Jacob, Philippe Renaud, Florian J Stadler, Il Kim.
Abstract
Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.Entities:
Keywords: cancer therapeutics; controlled drug delivery; hyperbranched polyethylene nanocapsule; microfluidic-assisted self-assembly; paclitaxel
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Year: 2014 PMID： 24610685 DOI： 10.1002/adma.201305753
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849