| Literature DB >> 24607539 |
Sigthor Petursson1, Sean M Scully2, Sigridur Jonsdottir3.
Abstract
The paper reports selective mono-etherification of the 2-, and 3-hydroxyl groups of methyl 4,6-O-isopropylidene-α-d-mannopyranoside using tin(II) chloride catalysed reactions of diaryldiazomethanes. By the use of different diazo compounds and the variation of the tin(II) chloride concentration the ether formation can be shifted from over 90% 3-selectivity to over 90% 2-selectivity.Entities:
Keywords: Catalysis; Diol; Protection; Regioselectivity; Tin(II) chloride
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Year: 2014 PMID： 24607539 DOI： 10.1016/j.carres.2014.02.016
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104