Literature DB >> 2460746

Regulation by the autophosphorylation site in overexpressed pp60c-src.

T E Kmiecik1, P J Johnson, D Shalloway.   

Abstract

We show that overexpressed pp60c-src is phosphorylated at Tyr-416 and has increased specific kinase activity when isolated from cells incubated with vanadate, a tyrosine phosphatase inhibitor. This supports the hypothesis that transient Tyr-416 phosphorylation modulates the activity of overexpressed pp60c-src in vivo. Mutagenesis indicates that Tyr-416 modulates pp60v-src activity as well.

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Year:  1988        PMID： 2460746      PMCID： PMC365532          DOI： 10.1128/mcb.8.10.4541-4546.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  24 in total

1.  Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.

Authors:  P J Johnson; P M Coussens; A V Danko; D Shalloway
Journal:  Mol Cell Biol       Date:  1985-05       Impact factor: 4.272

2.  Structurally and functionally modified forms of pp60v-src in Rous sarcoma virus-transformed cell lysates.

Authors:  M S Collett; S K Belzer; A F Purchio
Journal:  Mol Cell Biol       Date:  1984-07       Impact factor: 4.272

3.  Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity.

Authors:  G Weinmaster; M J Zoller; M Smith; E Hinze; T Pawson
Journal:  Cell       Date:  1984-06       Impact factor: 41.582

4.  Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation.

Authors:  F R Cross; H Hanafusa
Journal:  Cell       Date:  1983-09       Impact factor: 41.582

5.  Avian pp60c-src is more active when expressed in yeast than in vertebrate fibroblasts.

Authors:  J A Cooper; K Runge
Journal:  Oncogene Res       Date:  1987 Sep-Oct

6.  Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.

Authors:  L A Lipsich; A J Lewis; J S Brugge
Journal:  J Virol       Date:  1983-11       Impact factor: 5.103

7.  Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src.

Authors:  M A Snyder; J M Bishop; W W Colby; A D Levinson
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

8.  Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin.

Authors:  S J Parsons; D J McCarley; C M Ely; D C Benjamin; J T Parsons
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103

9.  A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential.

Authors:  M A Snyder; J M Bishop
Journal:  Virology       Date:  1984-07-30       Impact factor: 3.616

10.  The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme.

Authors:  D J Brown; J A Gordon
Journal:  J Biol Chem       Date:  1984-08-10       Impact factor: 5.157
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  42 in total

1.  Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

Authors:  R R Roussel; S R Brodeur; D Shalloway; A P Laudano
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

2.  NMR analysis of regioselectivity in dephosphorylation of a triphosphotyrosyl dodecapeptide autophosphorylation site of the insulin receptor by a catalytic fragment of LAR phosphotyrosine phosphatase.

Authors:  J P Lee; H Cho; W Bannwarth; E A Kitas; C T Walsh
Journal:  Protein Sci       Date:  1992-10       Impact factor: 6.725

3.  SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.

Authors:  Leslie A Cary; Richard A Klinghoffer; Christoph Sachsenmaier; Jonathan A Cooper
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

4.  En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.

Authors:  A J Muller; A M Pendergast; K Parmar; M H Havlik; N Rosenberg; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

5.  Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

Authors:  S M Murphy; M Bergman; D O Morgan
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

6.  Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

Authors:  S Bagrodia; S J Taylor; D Shalloway
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

7.  Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

Authors:  S Rong; S Segal; M Anver; J H Resau; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

8.  Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.

Authors:  S M Bell; D C Connolly; N J Maihle; J L Degen
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

9.  Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

Authors:  E A Clark; J S Brugge
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

10.  Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

Authors:  H Sabe; M Okada; H Nakagawa; H Hanafusa
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272
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