Elisângela Colpo1, Carlos Dalton D A Vilanova2, Luiz Gustavo B Reetz3, Marta M M F Duarte4, Iria Luiza G Farias3, Daiane F Meinerz2, Douglas O C Mariano2, Raquel G Vendrusculo5, Aline A Boligon6, Cristiane L Dalla Corte2, Roger Wagner5, Margareth L Athayde6, João Batista T da Rocha7. 1. Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, Brazil; Department of Nutrition, Center Franciscan University, Santa Maria, Brazil. 2. Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, Brazil. 3. Clinical Laboratory Analysis, University Hospital, Federal University of Santa Maria, Santa Maria, Brazil. 4. Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, Brazil; Lutheran University of Brazil, Santa Maria, Brazil. 5. Department of Technology and Food and Science, Federal University of Santa Maria, Santa Maria, Brazil. 6. Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria, Brazil. 7. Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: Jbtrocha@pq.cnpq.br.
Abstract
OBJECTIVE: The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals. METHOD: A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 ± 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5, 20 and 50 g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine. RESULTS: Consumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-α, and IFN-γ levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05). CONCLUSION: The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated.
RCT Entities:
OBJECTIVE: The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals. METHOD: A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 ± 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5, 20 and 50 g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine. RESULTS: Consumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-α, and IFN-γ levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05). CONCLUSION: The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated.
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Authors: Akinwunmi O Adeoye; John O Olanlokun; Habib Tijani; Segun O Lawal; Cecilia O Babarinde; Mobolaji T Akinwole; Clement O Bewaji Journal: Heliyon Date: 2019-09-17