Literature DB >> 24607221

Motor neuron death in ALS: programmed by astrocytes?

Sheila K Pirooznia1, Valina L Dawson2, Ted M Dawson3.   

Abstract

Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24607221      PMCID： PMC4040524          DOI： 10.1016/j.neuron.2014.02.024

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  14 in total

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Journal:  N Engl J Med       Date:  2001-05-31       Impact factor: 91.245

2.  Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.

Authors:  Han-Xiang Deng; Yong Shi; Yoshiaki Furukawa; Hong Zhai; Ronggen Fu; Erdong Liu; George H Gorrie; Mohammad S Khan; Wu-Yen Hung; Eileen H Bigio; Thomas Lukas; Mauro C Dal Canto; Thomas V O'Halloran; Teepu Siddique
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-24       Impact factor: 11.205

Review 3.  Necroptosis: the release of damage-associated molecular patterns and its physiological relevance.

Authors:  Agnieszka Kaczmarek; Peter Vandenabeele; Dmitri V Krysko
Journal:  Immunity       Date:  2013-02-21       Impact factor: 31.745

4.  Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.

Authors:  Lee J Martin; Zhiping Liu; Kevin Chen; Ann C Price; Yan Pan; Jason A Swaby; W Christopher Golden
Journal:  J Comp Neurol       Date:  2007-01-01       Impact factor: 3.215

5.  Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Authors:  Maria C N Marchetto; Alysson R Muotri; Yangling Mu; Alan M Smith; Gabriela G Cezar; Fred H Gage
Journal:  Cell Stem Cell       Date:  2008-12-04       Impact factor: 24.633

6.  Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Authors:  Francesco Paolo Di Giorgio; Gabriella L Boulting; Samuel Bobrowicz; Kevin C Eggan
Journal:  Cell Stem Cell       Date:  2008-12-04       Impact factor: 24.633

7.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.

Authors:  D R Rosen; T Siddique; D Patterson; D A Figlewicz; P Sapp; A Hentati; D Donaldson; J Goto; J P O'Regan; H X Deng
Journal:  Nature       Date:  1993-03-04       Impact factor: 49.962

Review 8.  Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.

Authors:  Jeffrey D Rothstein
Journal:  Ann Neurol       Date:  2009-01       Impact factor: 10.422

9.  Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.

Authors:  Yunjong Lee; Senthilkumar S Karuppagounder; Joo-Ho Shin; Yun-Il Lee; Han Seok Ko; Debbie Swing; Haisong Jiang; Sung-Ung Kang; Byoung Dae Lee; Ho Chul Kang; Donghoon Kim; Lino Tessarollo; Valina L Dawson; Ted M Dawson
Journal:  Nat Neurosci       Date:  2013-08-25       Impact factor: 24.884

Review 10.  An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.

Authors:  Melissa S Rotunno; Daryl A Bosco
Journal:  Front Cell Neurosci       Date:  2013-12-16       Impact factor: 5.505
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  16 in total

1.  TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.

Authors:  Thomas J LaRocca; Andrea Mariani; Linda R Watkins; Christopher D Link
Journal:  Neurobiol Dis       Date:  2019-06-21       Impact factor: 5.996

2.  Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Authors:  Hisham Qosa; Jessica Lichter; Mark Sarlo; Shashirekha S Markandaiah; Kevin McAvoy; Jean-Philippe Richard; Michael R Jablonski; Nicholas J Maragakis; Piera Pasinelli; Davide Trotti
Journal:  Glia       Date:  2016-05-09       Impact factor: 7.452

Review 3.  The Contribution of Necroptosis in Neurodegenerative Diseases.

Authors:  Lifei Shao; Shuping Yu; Wei Ji; Haizhen Li; Yilu Gao
Journal:  Neurochem Res       Date:  2017-04-05       Impact factor: 3.996

4.  Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.

Authors:  Maria Claudia Gonzalez Deniselle; Alejandro F De Nicola; Maria Meyer; Analia Lima
Journal:  Cell Mol Neurobiol       Date:  2022-10-11       Impact factor: 4.231

5.  Detection of the Cyanotoxins L-BMAA Uptake and Accumulation in Primary Neurons and Astrocytes.

Authors:  Vanessa X Tan; Claire Mazzocco; Bianca Varney; Dominique Bodet; Tristan A Guillemin; Alban Bessede; Gilles J Guillemin
Journal:  Neurotox Res       Date:  2017-08-30       Impact factor: 3.911

Review 6.  Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis.

Authors:  S Bräuer; V Zimyanin; A Hermann
Journal:  J Neural Transm (Vienna)       Date:  2018-02-08       Impact factor: 3.575

7.  Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer's Disease.

Authors:  I Dal Prà; A Chiarini; R Pacchiana; E Gardenal; B Chakravarthy; J F Whitfield; U Armato
Journal:  Curr Neuropharmacol       Date:  2014-07       Impact factor: 7.363

Review 8.  Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis.

Authors:  Ross D O'Shea; Chew L Lau; Natasha Zulaziz; Francesca L Maclean; David R Nisbet; Malcolm K Horne; Philip M Beart
Journal:  Front Neurosci       Date:  2015-02-20       Impact factor: 4.677

9.  Upregulation of the receptor-interacting protein 3 expression and involvement in neural tissue damage after spinal cord injury in mice.

Authors:  Haruo Kanno; Hiroshi Ozawa; Satoshi Tateda; Kenichiro Yahata; Eiji Itoi
Journal:  BMC Neurosci       Date:  2015-10-08       Impact factor: 3.288

Review 10.  Novel molecular biomarkers at the blood-brain barrier in ALS.

Authors:  Danijela Bataveljic; Milena Milosevic; Lidija Radenovic; Pavle Andjus
Journal:  Biomed Res Int       Date:  2014-05-11       Impact factor: 3.411
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