Literature DB >> 24607141

How amyloid precursor protein protects itself from cleavage.

Hsiang-Kai Lin1, Patrick C A van der Wel2.   

Abstract

In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 24607141      PMCID： PMC3996556          DOI： 10.1016/j.str.2014.02.008

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

1.  Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein.

Authors:  Jun-Xia Lu; Wai-Ming Yau; Robert Tycko
Journal:  Biophys J       Date:  2011-02-02       Impact factor: 4.033

2.  Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.

Authors:  Wen Chen; Eric Gamache; David J Rosenman; Jian Xie; Maria M Lopez; Yue-Ming Li; Chunyu Wang
Journal:  Nat Commun       Date:  2014       Impact factor: 14.919

Review 3.  Cholesterol as a co-solvent and a ligand for membrane proteins.

Authors:  Yuanli Song; Anne K Kenworthy; Charles R Sanders
Journal:  Protein Sci       Date:  2013-11-18       Impact factor: 6.725

4.  The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.

Authors:  Paul J Barrett; Yuanli Song; Wade D Van Horn; Eric J Hustedt; Johanna M Schafer; Arina Hadziselimovic; Andrew J Beel; Charles R Sanders
Journal:  Science       Date:  2012-06-01       Impact factor: 47.728

Review 5.  Influences of membrane mimetic environments on membrane protein structures.

Authors:  Huan-Xiang Zhou; Timothy A Cross
Journal:  Annu Rev Biophys       Date:  2013-03-01       Impact factor: 12.981

6.  Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.

Authors:  C De Jonghe; C Zehr; D Yager; C M Prada; S Younkin; L Hendriks; C Van Broeckhoven; C B Eckman
Journal:  Neurobiol Dis       Date:  1998-10       Impact factor: 5.996

7.  Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.

Authors:  Yuanli Song; Eric J Hustedt; Suzanne Brandon; Charles R Sanders
Journal:  Biochemistry       Date:  2013-07-18       Impact factor: 3.162

8.  An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Authors:  Yuan Tian; Bhramdeo Bassit; Deming Chau; Yue-Ming Li
Journal:  Nat Struct Mol Biol       Date:  2010-01-10       Impact factor: 15.369

9.  Structural characterization of the caveolin scaffolding domain in association with cholesterol-rich membranes.

Authors:  Cody L Hoop; V N Sivanandam; Ravindra Kodali; Matthew N Srnec; Patrick C A van der Wel
Journal:  Biochemistry       Date:  2011-12-13       Impact factor: 3.162

Review 10.  Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment.

Authors:  Concepción Abad; Luis Martínez-Gil; Silvia Tamborero; Ismael Mingarro
Journal:  Biochim Biophys Acta       Date:  2009-07-18
  10 in total

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