Literature DB >> 2460578

MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site.

J R Oksenberg1, A K Judd, C Ko, M Lim, R Fernandez, G K Schoolnik, L Steinman.   

Abstract

The S1 subunit of Pertussis toxin (PT) is responsible for the reactogenicity and in part the immunogenicity of Bordetella pertussis vaccine. The critical residues associated with the immunomodulatory effects of PT were located around Glu140 in the S1 subunit. In man, T cell responses to PT are directed at S1 peptides distinct from Glu140. Two such epitopes, p64-75 and p151-161, are immunogenic in a panel of individuals covering a wide range of HLA genotypes. The response to PT peptides is HLA class II restricted. The response to p64-75 is blocked by an anti-HLA-DQ mAb, while that to p151-161 is blocked by an anti-HLA-DR mAb. These findings may allow for the development of a B. pertussis vaccine free from reactogenicity.

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Year:  1988        PMID： 2460578      PMCID： PMC2189123          DOI： 10.1084/jem.168.5.1855

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  34 in total

1.  Constraints in T-B cooperation related to epitope topology on E. coli beta-galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation-dependent determinants.

Authors:  F Manca; A Kunkl; D Fenoglio; A Fowler; E Sercarz; F Celada
Journal:  Eur J Immunol       Date:  1985-04       Impact factor: 5.532

2.  Expression and immunological properties of the five subunits of pertussis toxin.

Authors:  A Nicosia; A Bartoloni; M Perugini; R Rappuoli
Journal:  Infect Immun       Date:  1987-04       Impact factor: 3.441

Review 3.  Vaccines for the future--an update.

Authors:  G L Ada; P D Jones
Journal:  Immunol Cell Biol       Date:  1987-02       Impact factor: 5.126

Review 4.  Bordetella pertussis toxins.

Authors:  A C Wardlaw; R Parton
Journal:  Pharmacol Ther       Date:  1982       Impact factor: 12.310

5.  Use of synthetic peptides to map antigenic sites of Bordetella pertussis toxin subunit S1.

Authors:  P Askelöf; K Rodmalm; J Abens; A Undén; T Bartfai
Journal:  J Infect Dis       Date:  1988-04       Impact factor: 5.226

6.  Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children.

Authors:  C L Cody; L J Baraff; J D Cherry; S M Marcy; C R Manclark
Journal:  Pediatrics       Date:  1981-11       Impact factor: 7.124

7.  Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein.

Authors:  M F Good; W L Maloy; M N Lunde; H Margalit; J L Cornette; G L Smith; B Moss; L H Miller; J A Berzofsky
Journal:  Science       Date:  1987-02-27       Impact factor: 47.728

8.  Antigen-presenting cells in human decidual tissue.

Authors:  J R Oksenberg; S Mor-Yosef; E Persitz; Y Schenker; E Mozes; C Brautbar
Journal:  Am J Reprod Immunol Microbiol       Date:  1986-07

9.  Possible role of V beta T cell receptor genes in susceptibility to collagen-induced arthritis in mice.

Authors:  S Banerjee; T M Haqqi; H S Luthra; J M Stuart; C S David
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307

10.  The specificity of cellular immune responses in guinea pigs. III. The precision of antigen recognition by T lymphocytes.

Authors:  C A Janeway; W E Paul
Journal:  J Exp Med       Date:  1976-12-01       Impact factor: 14.307
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  7 in total

1.  Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis.

Authors:  J W Petersen; P H Ibsen; K Hasløv; I Heron
Journal:  Infect Immun       Date:  1992-11       Impact factor: 3.441

2.  Further analysis of the sequence of the S1 subunit of pertussis toxin.

Authors:  M Pizza; M Bugnoli; P Pucci; R Siciliano; G Marino; R Rappuoli
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441

3.  Identification of human T-cell epitopes on the S4 subunit of pertussis toxin.

Authors:  J W Petersen; A Holm; P H Ibsen; K Hasløv; C Capiau; I Heron
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

4.  Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model.

Authors:  K H Mills; A Barnard; J Watkins; K Redhead
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

5.  Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin.

Authors:  J W Petersen; A Holm; P H Ibsen; K Hasløv; I Heron
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

6.  Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones.

Authors:  M T De Magistris; A Di Tommaso; M Domenighini; S Censini; A Tagliabue; J R Oksenberg; L Steinman; A K Judd; D O'Sullivan; R Rappuoli
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

7.  Human T cell clones define S1 subunit as the most immunogenic moiety of pertussis toxin and determine its epitope map.

Authors:  M T De Magistris; M Romano; A Bartoloni; R Rappuoli; A Tagliabue
Journal:  J Exp Med       Date:  1989-05-01       Impact factor: 14.307
  7 in total

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