Jonatan R Ruiz1, Idoia Labayen2, Francisco B Ortega1, Luis A Moreno3, Gerardo Rodriguez4, Christina Breidenassel5, Yannis Manios6, Anthony Kafatos7, Denes Molnar8, Stephaan De Henauw9, Frederic Gottrand10, Kurt Widhalm11, Manuel J Castillo12, Michael Sjöström13. 1. 1] PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain [2] Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden. 2. 1] Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain [2] GENUD "Growth, Exercise, Nutrition and Development" Research Group, Zaragoza, Spain. 3. 1] GENUD "Growth, Exercise, Nutrition and Development" Research Group, Zaragoza, Spain [2] Department of Health and Human Performance, School of Health Sciences, University of Zaragoza, Zaragoza, Spain. 4. 1] GENUD "Growth, Exercise, Nutrition and Development" Research Group, Zaragoza, Spain [2] Department of Pediatrics, University of Zaragoza, Zaragoza, Spain. 5. Institut für Ernährungs und Lebensmittelwissenschaften - Humanernährung, Rheinische Friedrich-Wilhelms Universität Bonn, Bonn, Germany. 6. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. 7. Preventive Medicine and Nutrition Unit, School of Medicine, University of Crete, Crete, Greece. 8. Department of Pediatrics, University of Pecs, Pecs, Hungary. 9. Department of Public Health, Ghent University, Ghent, Belgium. 10. INSERM U995, Faculté de Médecine, University of Lille, Lille, France. 11. Department of Pediatrics, Division of Clinical Nutrition, Medical University of Vienna, Vienna, Austria. 12. Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain. 13. Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.
Abstract
BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and the AST/ALT ratio was computed. RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and the AST/ALT ratio was computed. RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
Authors: Idoia Labayen; Jonatan R Ruiz; Inge Huybrechts; Francisco B Ortega; Manuel Castillo; Michael Sjöstrom; Marcela González-Gross; Yannis Manios; Kurt Widhalm; Anthony Kafatos; Christina Breidenassel; Gerardo Rodríguez; Jean Dallongeville; Frédéric Gottrand; Luis A Moreno Journal: J Physiol Biochem Date: 2017-01-06 Impact factor: 4.158
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