| Literature DB >> 24602900 |
Tao He1, Qing-Yao Wang2, Jing-Zhen Shi3, Tian-Yun Fan2, Chen Yan1, Lie-Jun Huang1, Sheng Liu1, Xiao-Jiang Hao4, Shu-Zhen Mu5.
Abstract
The halogenated and oxidized derivatives (1a-1e, 1a'-1c', 2a-2d, 2a'-2b', 3a-3e, 3' and 3a'-3b') of schizandrin (1), schizandrin B (2) and schisanhenol (3) were synthesized. The hepatoprotective effects of these dibenzocyclooctadiene lignan analogues against CCl4-induced injury were preliminarily evaluated. Most of the analogues exhibited higher protective effects than the positive control biphenyldicarboxylate (DDB). Among these active analogues, dichloroschisanhenol (3a) exhibited the strongest protective activity (cell survival rate exceeding 98.0%).Entities:
Keywords: Dibenzocyclooctadiene lignan derivatives; Hepatoprotective effect; Schisanhenol; Schizandrin; Schizandrin B
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Year: 2014 PMID： 24602900 DOI： 10.1016/j.bmcl.2014.02.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823