Lucky H Sekhon1, Rachel S Gerber2, Andrei Rebarber3, Daniel H Saltzman3, Chad K Klauser3, Simi Gupta3, Nathan S Fox4. 1. Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. 2. Weill-Cornell Medical College, New York, New York. 3. Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York; Maternal Fetal Medicine Associates, PLLC, New York, New York. 4. Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York; Maternal Fetal Medicine Associates, PLLC, New York, New York. Electronic address: nfox@mfmnyc.com.
Abstract
OBJECTIVE: To estimate the effect of oocyte donation on pregnancy outcomes in patients with twin pregnancies conceived via IVF. DESIGN: Retrospective cohort study. SETTING: Patients with IVF twin pregnancies delivered by one maternal-fetal medicine practice from 2005 to 2013. PATIENT(S): Fifty-six patients with IVF twin pregnancies who had oocyte donation and 56 age-matched controls with IVF twin pregnancies who used autologous oocytes. We excluded women aged >50 years because there were no age-matched controls aged >50 years using autologous oocytes. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Gestational hypertension, pre-eclampsia. RESULT(S): The baseline characteristics were similar between the groups, including maternal age, race, parity, chorionicity, and comorbidities. The mean (±SD) age was 43.0 ± 6.0 vs. 41.9 ± 1.7 years. There were no differences in outcomes between the groups in regard to preterm birth, birth weight, or gestational diabetes. There was a greater incidence of gestational hypertension (32.1% vs. 13.0%) and pre-eclampsia (28.3% vs. 13.0%) in the group that underwent IVF with donor oocytes. CONCLUSION(S): In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and pre-eclampsia. However, this did not translate into increased rates of preterm birth or low birth weight. Patients who require oocyte donation should be carefully counseled regarding the increased risk for pre-eclampsia and gestational hypertension but should be reassured that oocyte donation does not seem to lead to other adverse outcomes.
OBJECTIVE: To estimate the effect of oocyte donation on pregnancy outcomes in patients with twin pregnancies conceived via IVF. DESIGN: Retrospective cohort study. SETTING:Patients with IVF twin pregnancies delivered by one maternal-fetal medicine practice from 2005 to 2013. PATIENT(S): Fifty-six patients with IVF twin pregnancies who had oocyte donation and 56 age-matched controls with IVF twin pregnancies who used autologous oocytes. We excluded women aged >50 years because there were no age-matched controls aged >50 years using autologous oocytes. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Gestational hypertension, pre-eclampsia. RESULT(S): The baseline characteristics were similar between the groups, including maternal age, race, parity, chorionicity, and comorbidities. The mean (±SD) age was 43.0 ± 6.0 vs. 41.9 ± 1.7 years. There were no differences in outcomes between the groups in regard to preterm birth, birth weight, or gestational diabetes. There was a greater incidence of gestational hypertension (32.1% vs. 13.0%) and pre-eclampsia (28.3% vs. 13.0%) in the group that underwent IVF with donor oocytes. CONCLUSION(S): In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and pre-eclampsia. However, this did not translate into increased rates of preterm birth or low birth weight. Patients who require oocyte donation should be carefully counseled regarding the increased risk for pre-eclampsia and gestational hypertension but should be reassured that oocyte donation does not seem to lead to other adverse outcomes.
Authors: Melissa M Amyx; Paul S Albert; Alaina M Bever; Stefanie N Hinkle; John Owen; William A Grobman; Roger B Newman; Edward K Chien; Robert E Gore-Langton; Germaine M Buck Louis; Katherine L Grantz Journal: Paediatr Perinat Epidemiol Date: 2019-09-03 Impact factor: 3.103
Authors: Silvia Vannuccini; Vicki L Clifton; Ian S Fraser; Hugh S Taylor; Hilary Critchley; Linda C Giudice; Felice Petraglia Journal: Hum Reprod Update Date: 2015-09-22 Impact factor: 15.610