Malignant hyperthermia in the intensive care setting.

Malignant hyperthermia (MH) is a life-threatening, inherited disorder of skeletal muscle calcium homeostasis. In susceptible individuals, exposure to trigger agents such as volatile anesthetics and depolarizing muscle relaxants, typically administered to induce or maintain general anesthesia, may lead to a hypermetabolic muscular syndrome [1]. Recently, an anesthetic conserving device (AnaConDa®; Sedana Medical AB, Geretsried, Germany) was introduced for sedation of intensive care patients using volatile anesthetics, associated with shorter wake-up and extubation time, reduced duration of mechanical ventilation and earlier hospital discharge [2].

After obtaining oral and written consent, we report the case of a 59-year-old male patient, who was hospitalized due to persistent lumbalgia. On the second day of the patient’s hospital stay, increasing dyspnea and tachypnea required admission to the ICU and tracheal intubation. Sedation was maintained by propofol and sufentanil infusion. A chest radiography revealed bilateral pulmonary infiltration, suggestive of influenza pneumonia. Moxifloxacin, piperacillin/tazobactam and oseltamivir were started immediately. After 4 days on mechanical ventilation, sedation needed to be escalated and an anesthetic conserving device for additional sevoflurane sedation was installed. Suddenly, after 5 hours of sevoflurane administration, hemodynamic instability occurred. The arterial blood pressure rapidly decreased to 78/44 mmHg, while the heart rate remained constant around 110 beats/minute. Arterial blood gas analysis revealed severe acidosis (pH, 7.17; carbon dioxide partial pressure, 70.4 mmHg; oxygen partial pressure, 104 mmHg (fraction of inspired oxygen, 50%); base excess, 9.8; lactate, 0.6 mmol/l), and a rapid increase of body temperature from 39.6 to 40.7 °C within 30 minutes was noticed. Creatine kinase and myoglobin levels were significantly increased to maximum levels of 3,455 U/l and 4,197 μg/l, respectively, due to acute rhabdomyolysis. Since MH was suspected, sevoflurane application was discontinued, and dantrolene (225 mg) was administered intravenously, resulting in gradual improvement of the hemodynamic and metabolic situation. The further course was unremarkable. The subsequent ICU stay remained uneventful and the patient was extubated on day 17 without neurological deficits. Nine months after the suspected MH event, the patient underwent muscle biopsy and in vitro contracture testing according to the guidelines of the European MH group. The patient’s MH susceptibility was thus confirmed, by significant contractures at the defined thresholds after halothane and caffeine exposure [3].

The presented case underlines that MH is an important differential diagnosis in intensive care patients with hemodynamic and metabolic breakdown if volatile anesthetics are used for sedation. Hence, every ICU physician must be aware of the symptoms of MH to rapidly initiate sufficient treatment.

Abbreviations

MH: Malignant hyperthermia.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

FS accompanied the data acquisition, collected and analyzed the data and drafted the manuscript. SM collected the data and performed the muscle biopsy. SJ collected data. NR participated in the design of the study. All authors read and approved the final manuscript.