BACKGROUND AND PURPOSE: Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients. METHODS: Fifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification. RESULTS: No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients. CONCLUSIONS: Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.
BACKGROUND AND PURPOSE:Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PDpatients. METHODS: Fifteen PDpatients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification. RESULTS: No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients. CONCLUSIONS: Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PDpatients.
Authors: Aysegul Gunduz; Hokuto Morita; P Justin Rossi; William L Allen; Ron L Alterman; Helen Bronte-Stewart; Christopher R Butson; David Charles; Sjaak Deckers; Coralie de Hemptinne; Mahlon DeLong; Darin Dougherty; Jens Ellrich; Kelly D Foote; James Giordano; Wayne Goodman; Benjamin D Greenberg; David Greene; Robert Gross; Jack W Judy; Edward Karst; Alexander Kent; Brian Kopell; Anthony Lang; Andres Lozano; Codrin Lungu; Kelly E Lyons; Andre Machado; Hubert Martens; Cameron McIntyre; Hoon-Ki Min; Joseph Neimat; Jill Ostrem; Sat Pannu; Francisco Ponce; Nader Pouratian; Donnie Reymers; Lauren Schrock; Sameer Sheth; Ludy Shih; Scott Stanslaski; G Karl Steinke; Paul Stypulkowski; Alexander I Tröster; Leo Verhagen; Harrison Walker; Michael S Okun Journal: Int J Neurosci Date: 2015-05-25 Impact factor: 2.292