| Literature DB >> 24601669 |
Ikuko Nagasawa1, Akira Kaneko, Toshihiro Suzuki, Kazuto Nishio, Kaoru Kinoshita, Motto Shiro, Kiyotaka Koyama.
Abstract
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.Entities:
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Year: 2014 PMID： 24601669 DOI： 10.1021/np401046z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050