Literature DB >> 24601116

[Insufficient sugammadex effect in an obese pregnant woman undergoing cesarean section under general anesthesia].

Kenji Kayashima1, Reiko Sozen2, Dan Okura1.   

Abstract

A 32-year-old pregnant woman (height 162 cm, weight 86 kg, age of fetus 25 weeks) without preoperative complications underwent an emergent cesarean section under general anesthesia. She was intubated with a 7.0-mm tracheal tube 40 s after receiving rocuronium 0.93 mg x kg(-1) and thiamilal 375 mg. Anesthesia was maintained with oxygen, air, sevoflurane 1.0-2.5%, and fentanyl 425 microg. Nine minutes after the end of surgery (operation time 71 minutes), a train-of-four count of 2 with 20 spontaneous breaths was noted, and sugammadex 2.3 mg x kg(-1) was administered. However, the train-of-four count was 3 even five minutes after sugammadex administration. Fifteen minutes after sugammadex administration (train-of-four ratio 14%), she received atropine 0.5 mg and neostigmine 1.0 mg. Ten minutes later, the train-of-four ratio increased to 89%, and the patient was successfully extubated with no respiratory suppression. We speculate that the rocuronium dose (0.93 mg x kg(-1)) was too high in this obese patient, and sugammadex dose at the end of the surgery was not enough for reversal of rocuronium-induced neuromuscular blockade.

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Year:  2014        PMID: 24601116

Source DB:  PubMed          Journal:  Masui        ISSN: 0021-4892


  3 in total

1.  The Effects of Sugammadex on Progesterone Levels in Pregnant Rats.

Authors:  Tayfun Et; Ahmet Topal; Atilla Erol; Aybars Tavlan; Alper Kılıçaslan; Sema Tuncer Uzun
Journal:  Balkan Med J       Date:  2015-04-01       Impact factor: 2.021

2.  Observational study on patterns of neuromuscular blockade reversal.

Authors:  Timur Dubovoy; Michelle Housey; Scott Devine; Sachin Kheterpal
Journal:  BMC Anesthesiol       Date:  2016-10-22       Impact factor: 2.217

3.  Prolonged neuromuscular blockade and insufficient reversal after sugammadex administration in cesarean section under general anesthesia: a case report.

Authors:  Kuniaki Moriwaki; Kenji Kayashima
Journal:  JA Clin Rep       Date:  2019-04-11
  3 in total

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