Shu-Wei Nie1, Xiao-Feng Wang2, Zong-Chun Tang2. 1. Department of Emergency, The Fourth Peoples Hospital in Shaanxi Province Xi'an 710043, China. 2. Department of Neurosurgery, The Third Hospital of Chinese Peoples Liberation Army Baoji 721004, China.
Abstract
OBJECTIVE: Ischemic stroke (IS) results from interrupted blood flow to the brain and can be caused by formation of atherosclerotic plaques in blood vessels. Previous studies have suggested a contribution of matrix metalloproteinases (MMP) to plaque formation and stroke risk. Here, we explored associations between two MMPs, MMP-2 and MMP-9, and IS. METHODS: There were 396 IS patients and 400 control individuals involved in this study. The MMP-2 -1306C/T and -735C/T polymorphisms and MMP-9 -1562C/T polymorphism were analyzed by restriction fragment length polymorphism (RFLP) from patient blood samples, and the relationships to IS were analyzed by logistic regression. RESULTS: Genotype and allele frequencies of MMP-2 -1306C/T did not differ statistically (P>0.05), but those of MMP-2 -735C/T and MMP-9 1562C/T did differ between IS and control samples (P<0.05). While MMP-2 -1306C/T polymorphism was not associated with increased risk of IS, MMP-2 -735C allele was associated with a 1.5-fold increase in IS incidence (OR=1.516, 95% CI=1.185-1.940, P=0.001), and MMP-9 -1562T allele was associated with a 1.5-fold increase in IS incidence (OR=1.543, 95% CI=1.144-2.080, P=0.004). CONCLUSION: MMP-2 -735C and MMP-9 -1562T may act as IS susceptibility alleles.
OBJECTIVE:Ischemic stroke (IS) results from interrupted blood flow to the brain and can be caused by formation of atherosclerotic plaques in blood vessels. Previous studies have suggested a contribution of matrix metalloproteinases (MMP) to plaque formation and stroke risk. Here, we explored associations between two MMPs, MMP-2 and MMP-9, and IS. METHODS: There were 396 IS patients and 400 control individuals involved in this study. The MMP-2-1306C/T and -735C/T polymorphisms and MMP-9-1562C/T polymorphism were analyzed by restriction fragment length polymorphism (RFLP) from patient blood samples, and the relationships to IS were analyzed by logistic regression. RESULTS: Genotype and allele frequencies of MMP-2-1306C/T did not differ statistically (P>0.05), but those of MMP-2-735C/T and MMP-9 1562C/T did differ between IS and control samples (P<0.05). While MMP-2-1306C/T polymorphism was not associated with increased risk of IS, MMP-2 -735C allele was associated with a 1.5-fold increase in IS incidence (OR=1.516, 95% CI=1.185-1.940, P=0.001), and MMP-9 -1562T allele was associated with a 1.5-fold increase in IS incidence (OR=1.543, 95% CI=1.144-2.080, P=0.004). CONCLUSION:MMP-2 -735C and MMP-9 -1562T may act as IS susceptibility alleles.
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