Literature DB >> 24599981

Emergence of G186D mutation in the presence of R292K mutation in an immunocompromised child infected with influenza A/H3N2 virus, treated with oseltamivir.

Hong Kai Lee1, Julian Wei-Tze Tang, Tze Ping Loh, Debra Han-Lin Kong, Yew-Weng Lau, Hui Kim Yap, Evelyn Siew-Chuan Koay.   

Abstract

An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by day 10.

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Year:  2014        PMID： 24599981      PMCID： PMC3993657          DOI： 10.1128/JCM.00538-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

Review 1.  Resistance of influenza viruses to neuraminidase inhibitors--a review.

Authors:  J L McKimm-Breschkin
Journal:  Antiviral Res       Date:  2000-07       Impact factor: 5.970

Review 2.  Functional balance between haemagglutinin and neuraminidase in influenza virus infections.

Authors:  Ralf Wagner; Mikhail Matrosovich; Hans-Dieter Klenk
Journal:  Rev Med Virol       Date:  2002 May-Jun       Impact factor: 6.989

3.  Single amino acid substitutions in the hemagglutinin of influenza A/Singapore/21/04 (H3N2) increase virus growth in embryonated chicken eggs.

Authors:  Bin Lu; Helen Zhou; Winnie Chan; George Kemble; Hong Jin
Journal:  Vaccine       Date:  2006-06-09       Impact factor: 3.641

Review 4.  Structural basis of immune recognition of influenza virus hemagglutinin.

Authors:  I A Wilson; N J Cox
Journal:  Annu Rev Immunol       Date:  1990       Impact factor: 28.527

5.  Positive selection on the H3 hemagglutinin gene of human influenza virus A.

Authors:  R M Bush; W M Fitch; C A Bender; N J Cox
Journal:  Mol Biol Evol       Date:  1999-11       Impact factor: 16.240

6.  A comparison of pyrosequencing and neuraminidase inhibition assays for the detection of oseltamivir-resistant pandemic influenza A(H1N1) 2009 viruses.

Authors:  Yi-Mo Deng; Natalie Caldwell; Aeron Hurt; Tim Shaw; Anne Kelso; Glenys Chidlow; Simon Williams; David Smith; Ian Barr
Journal:  Antiviral Res       Date:  2011-03-02       Impact factor: 5.970

7.  Assessment of development of resistance to antivirals in the ferret model of influenza virus infection.

Authors:  M Louise Herlocher; Rachel Truscon; Rob Fenton; Alexander Klimov; Stephanie Elias; Suzanne E Ohmit; Arnold S Monto
Journal:  J Infect Dis       Date:  2003-10-17       Impact factor: 5.226

8.  Diagnostic testing for pandemic influenza in Singapore: a novel dual-gene quantitative real-time RT-PCR for the detection of influenza A/H1N1/2009.

Authors:  Hong Kai Lee; Chun Kiat Lee; Tze Ping Loh; Julian Wei-Tze Tang; Lily Chiu; Paul A Tambyah; Sunil K Sethi; Evelyn Siew-Chuan Koay
Journal:  J Mol Diagn       Date:  2010-08-05       Impact factor: 5.568

9.  The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en.

Authors:  T J Blick; A Sahasrabudhe; M McDonald; I J Owens; P J Morley; R J Fenton; J L McKimm-Breschkin
Journal:  Virology       Date:  1998-06-20       Impact factor: 3.616

10.  Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.

Authors:  J L McKimm-Breschkin; A Sahasrabudhe; T J Blick; M McDonald; P M Colman; G J Hart; R C Bethell; J N Varghese
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103
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  3 in total

1.  Application of a seven-target pyrosequencing assay to improve the detection of neuraminidase inhibitor-resistant Influenza A(H3N2) viruses.

Authors:  Daisuke Tamura; Margaret Okomo-Adhiambo; Vasiliy P Mishin; Zhu Guo; Xiyan Xu; Julie Villanueva; Alicia M Fry; James Stevens; Larisa V Gubareva
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

2.  Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009-2013.

Authors:  Hong Kai Lee; Julian Wei-Tze Tang; Tze Ping Loh; Aeron C Hurt; Lynette Lin-Ean Oon; Evelyn Siew-Chuan Koay
Journal:  PLoS One       Date:  2015-01-30       Impact factor: 3.240

Review 3.  Current Approaches for Diagnosis of Influenza Virus Infections in Humans.

Authors:  Sai Vikram Vemula; Jiangqin Zhao; Jikun Liu; Xue Wang; Santanu Biswas; Indira Hewlett
Journal:  Viruses       Date:  2016-04-12       Impact factor: 5.048
  3 in total

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