RATIONALE AND OBJECTIVE: The relationship between clinically effective antipsychotic drugs in obsessive-compulsive disorders (OCD) and binding affinities to cloned dopamine and serotonin receptor subtypes was analyzed in an effort to clarify the contribution of individual receptor subtypes to medication response. METHODS: Meta-analysis was used to update previous meta-analyses of effectiveness data of add-on antipsychotic drugs to selective serotonin reuptake inhibitors (SSRIs) in OCD. Twelve previously analyzed randomized controlled trials (RCTs) and one new RCT were included. We performed a metaregression using a mixed-effect model to examine the association between antipsychotic's effectiveness and receptor affinity. RESULTS: A total of 5 treatment arms obtained from 13 RCTs (431 patients) were included in our study. The results of our metaregression showed a significant association between D2 and D3 dopamine receptor affinities and effectiveness in OCD (respectively, slope = -0.36, p = 0.01; and slope = -0.50, p = 0.01) whereas other dopamine receptors and serotonin receptors were not significantly associated. CONCLUSIONS: These observations suggest that increasing D2 and D3 dopamine receptor binding affinities enhances antipsychotics' effectiveness in obsessive-compulsive disorders.
RATIONALE AND OBJECTIVE: The relationship between clinically effective antipsychotic drugs in obsessive-compulsive disorders (OCD) and binding affinities to cloned dopamine and serotonin receptor subtypes was analyzed in an effort to clarify the contribution of individual receptor subtypes to medication response. METHODS: Meta-analysis was used to update previous meta-analyses of effectiveness data of add-on antipsychotic drugs to selective serotonin reuptake inhibitors (SSRIs) in OCD. Twelve previously analyzed randomized controlled trials (RCTs) and one new RCT were included. We performed a metaregression using a mixed-effect model to examine the association between antipsychotic's effectiveness and receptor affinity. RESULTS: A total of 5 treatment arms obtained from 13 RCTs (431 patients) were included in our study. The results of our metaregression showed a significant association between D2 and D3 dopamine receptor affinities and effectiveness in OCD (respectively, slope = -0.36, p = 0.01; and slope = -0.50, p = 0.01) whereas other dopamine receptors and serotonin receptors were not significantly associated. CONCLUSIONS: These observations suggest that increasing D2 and D3 dopamine receptor binding affinities enhances antipsychotics' effectiveness in obsessive-compulsive disorders.
Authors: Neil M Richtand; Jeffrey A Welge; Aaron D Logue; Paul E Keck; Stephen M Strakowski; Robert K McNamara Journal: Neuropsychopharmacology Date: 2007-01-24 Impact factor: 7.853
Authors: M Karayiorgou; C Sobin; M L Blundell; B L Galke; L Malinova; P Goldberg; J Ott; J A Gogos Journal: Biol Psychiatry Date: 1999-05-01 Impact factor: 13.382
Authors: Damiaan Denys; Froukje de Vries; Danielle Cath; Martijn Figee; Nienke Vulink; Dick J Veltman; Thalia F van der Doef; Ronald Boellaard; Herman Westenberg; Anton van Balkom; Adriaan A Lammertsma; Bart N M van Berckel Journal: Eur Neuropsychopharmacol Date: 2013-07-19 Impact factor: 4.600
Authors: Dan J Stein; Daniel L C Costa; Christine Lochner; Euripedes C Miguel; Y C Janardhan Reddy; Roseli G Shavitt; Odile A van den Heuvel; H Blair Simpson Journal: Nat Rev Dis Primers Date: 2019-08-01 Impact factor: 52.329
Authors: Christopher Pittenger; Brian P Brennan; Lorrin Koran; Carol A Mathews; Gerald Nestadt; Michele Pato; Katharine A Phillips; Carolyn I Rodriguez; H Blair Simpson; Petros Skapinakis; Dan J Stein; Eric A Storch Journal: Psychiatry Res Date: 2021-03-04 Impact factor: 11.225
Authors: Naomi A Fineberg; Annemieke M Apergis-Schoute; Matilde M Vaghi; Paula Banca; Claire M Gillan; Valerie Voon; Samuel R Chamberlain; Eduardo Cinosi; Jemma Reid; Sonia Shahper; Edward T Bullmore; Barbara J Sahakian; Trevor W Robbins Journal: Int J Neuropsychopharmacol Date: 2018-01-01 Impact factor: 5.176