OBJECTIVE: There is evidence for the existence of bone disease in epileptic patients. The goal of this study was the comparison of serum levels calcium, alkaline phosphatase (ALKP) and 25-hydroxyvitamin D in ambulatory epileptic children in order to evaluate the bone metabolism in epileptic patients. METHODS: In this prospective analytical study 48 ambulatory epileptic children who were treated by antiepileptic drugs for atleast 6 months as case group compared with 48 children who were age and gender matched as control group. Patients with any neurological deficits and other systemic diseases were excluded. Data was collected by questionnaire and analyzed by spss software version 18. RESULTS: Mean of calcium level in case and control groups was 9.91 ±0.675 and 10.08 ±0.331 mg/dl respectively, means of ALKP in case were 703 and 607.75 IU/L respectively. Only difference between the ALKP were significant. Calcium levels, ALKP and vitmain D in any of the two groups were not associated with age and a sex but ALKP level in patients was higher and it was statistically siginificant. Calcium levels, ALKP and vitamin D in patients with drug type, dosage and duration of treatment were irrelevant. CONCLUSION: The results of this study showed that calcium and vitamin D levels were in normal ranges in epileptic and control groups but ALKP levels were significantly higher in epileptic group which can be a valuable indicator of bone metabolism in these patients.
OBJECTIVE: There is evidence for the existence of bone disease in epilepticpatients. The goal of this study was the comparison of serum levels calcium, alkaline phosphatase (ALKP) and 25-hydroxyvitamin D in ambulatory epilepticchildren in order to evaluate the bone metabolism in epilepticpatients. METHODS: In this prospective analytical study 48 ambulatory epilepticchildren who were treated by antiepileptic drugs for atleast 6 months as case group compared with 48 children who were age and gender matched as control group. Patients with any neurological deficits and other systemic diseases were excluded. Data was collected by questionnaire and analyzed by spss software version 18. RESULTS: Mean of calcium level in case and control groups was 9.91 ±0.675 and 10.08 ±0.331 mg/dl respectively, means of ALKP in case were 703 and 607.75 IU/L respectively. Only difference between the ALKP were significant. Calcium levels, ALKP and vitmain D in any of the two groups were not associated with age and a sex but ALKP level in patients was higher and it was statistically siginificant. Calcium levels, ALKP and vitamin D in patients with drug type, dosage and duration of treatment were irrelevant. CONCLUSION: The results of this study showed that calcium and vitamin D levels were in normal ranges in epileptic and control groups but ALKP levels were significantly higher in epileptic group which can be a valuable indicator of bone metabolism in these patients.
Authors: Divine C Nwafor; Allison L Brichacek; Afroz S Mohammad; Jessica Griffith; Brandon P Lucke-Wold; Stanley A Benkovic; Werner J Geldenhuys; Paul R Lockman; Candice M Brown Journal: J Cent Nerv Syst Dis Date: 2019-04-09