Animesh Deb1, Shuvankar Mukherjee2, Bikram Kumar Saha3, Biswanath Sharma Sarkar4, Jyotirmay Pal5, Naren Pandey6, T K Nandi7, Sayantani Nandi8. 1. Associate Professor, Department of General Medicine, Mata Gujri Memorial Medical College and L.S.K Hospital , Kishanganj, Bihar, India and Consultant, Lifestyle Clinic: Allergy, Asthma and COPD care unit, Kolkata, West Bengal, India . 2. Assistant Professor, Department of Community Medicine, Calcutta National Medical College & Hospital , Kolkata, West Bengal, India . 3. Assistant Professor, Department of General Medicine, North Bengal Medical College & Hospital , Siliguri, West Bengal,India . 4. Associate Professor, Department of General Medicine, Bankura Sammilani Medical College & Hospital , Bankura, West Bengal, India . 5. Associate Professor, Department of General Medicine, Institute of Post Graduate Medical Education & Research , Kolkata, West Bengal, India . 6. Allergy Specialist, Belle View Clinic , Kolkata, West Bengal, India . 7. Senior Consultant, Department of ENT, ESI Hospital , Asansol, West Bengal, India . 8. Consultant Biotechnologist, Department of Biotechnology, Asansol, West Bengal, India .
Abstract
BACKGROUND: Allergic Rhinitis (AR) though quite common in India, does not receive its due importance as it deserves. AIM OF THE STUDY: To identify the demographic and clinical profile of the patients with AR and to find the association of pre-dominant disease symptoms with common allergens, type and severity of the disease and other co-morbidities. SETTINGS AND DESIGN: This clinic-based cross-sectional, observational study was conducted among adult patients presenting with signs and symptoms suggestive of AR. METHODS AND MATERIAL: Consecutive 548 patients were initially screened for possible cases of AR by proper history taking and physical examination and confirmation was done by a battery of investigations, including modified skin prick test. A total of 462 patients who were finally diagnosed with AR were included in the study. Categorization of these patients was done following Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Pulmonary function tests and X-ray/CT-scan of the para-nasal sinuses were done to confirm the presence of bronchial asthma and sinusitis, respectively. STATISTICAL ANALYSIS USED: Data were analyzed by Statistical Package for Social Scientists (SPSS version 10). Z-test was applied to compare between two rates, at 5% level of significance. RESULTS: Proportion of "blockers" was found to be much higher than that of "sneezers-runners" (64.1% vs. 35.9%). "Blockers" had significantly more sensitization to polyvalent house dust, house dust mites and fungi (p < 0.05), while, "sneezers-runners" had more sensitization to pollens (p < 0.05). Significantly more "blockers" had "moderate/severe persistent" and "mild persistent" types of the disease (p < 0.05), while "mild intermittent" and moderate/severe intermittent" type of disease were significantly more common among "sneezers-runners" (p < 0.05). Both bronchial asthma and sinusitis were significantly more common among the "blockers" (p < 0.05). CONCLUSION: It can be concluded from the present study that the clinical profiles of the two main categories of AR namely "sneezers-runners" and "blockers" were distinct from each other. This knowledge can be useful to physicians at all levels for better management of patients with AR.
BACKGROUND: Allergic Rhinitis (AR) though quite common in India, does not receive its due importance as it deserves. AIM OF THE STUDY: To identify the demographic and clinical profile of the patients with AR and to find the association of pre-dominant disease symptoms with common allergens, type and severity of the disease and other co-morbidities. SETTINGS AND DESIGN: This clinic-based cross-sectional, observational study was conducted among adult patients presenting with signs and symptoms suggestive of AR. METHODS AND MATERIAL: Consecutive 548 patients were initially screened for possible cases of AR by proper history taking and physical examination and confirmation was done by a battery of investigations, including modified skin prick test. A total of 462 patients who were finally diagnosed with AR were included in the study. Categorization of these patients was done following Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Pulmonary function tests and X-ray/CT-scan of the para-nasal sinuses were done to confirm the presence of bronchial asthma and sinusitis, respectively. STATISTICAL ANALYSIS USED: Data were analyzed by Statistical Package for Social Scientists (SPSS version 10). Z-test was applied to compare between two rates, at 5% level of significance. RESULTS: Proportion of "blockers" was found to be much higher than that of "sneezers-runners" (64.1% vs. 35.9%). "Blockers" had significantly more sensitization to polyvalent house dust, house dust mites and fungi (p < 0.05), while, "sneezers-runners" had more sensitization to pollens (p < 0.05). Significantly more "blockers" had "moderate/severe persistent" and "mild persistent" types of the disease (p < 0.05), while "mild intermittent" and moderate/severe intermittent" type of disease were significantly more common among "sneezers-runners" (p < 0.05). Both bronchial asthma and sinusitis were significantly more common among the "blockers" (p < 0.05). CONCLUSION: It can be concluded from the present study that the clinical profiles of the two main categories of AR namely "sneezers-runners" and "blockers" were distinct from each other. This knowledge can be useful to physicians at all levels for better management of patients with AR.
Authors: D Strachan; B Sibbald; S Weiland; N Aït-Khaled; G Anabwani; H R Anderson; M I Asher; R Beasley; B Björkstén; M Burr; T Clayton; J Crane; P Ellwood; U Keil; C Lai; J Mallol; F Martinez; E Mitchell; S Montefort; N Pearce; C Robertson; J Shah; A Stewart; E von Mutius; H Williams Journal: Pediatr Allergy Immunol Date: 1997-11 Impact factor: 6.377
Authors: Horng-Chyuan Lin; Sang-Heon Cho; Aloke Gopal Ghoshal; Abdul Razak Bin Abdul Muttalif; Sanguansak Thanaviratananich; Shalini Bagga; Rab Faruqi; Shiva Sajjan; Camilla L Cahill; Kim K Hamrosi; De Yun Wang Journal: Medicine (Baltimore) Date: 2016-07 Impact factor: 1.889
Authors: Aloke Gopal Ghoshal; G D Ravindran; Paras Gangwal; Girish Rajadhyaksha; Sang-Heon Cho; Abdul Razak Bin Abdul Muttalif; Horng-Chyuan Lin; Sanguansak Thanaviratananich; Shalini Bagga; Rab Faruqi; Shiva Sajjan; Pradeep Shetty; Raeesuddin Syed; Kim K Hamrosi; De Yun Wang Journal: Lung India Date: 2016 Nov-Dec