Anita B Kale1, Sunil B Kale2, Shivaji S Chalak3, Tankhiwale S R4, G Bang5, Mohit Agrawal6, Meghali Kaple7. 1. Professor and Head, Department of Biochemistry, Jawaharlal Nehru Medical College, DMIMS (Deemed University) Wardha, India . 2. Assistant Professor, Department of Pharmacology, Padmashri Dr. Vithalrao Vikhe Patil Foundation Medical College , Ahemednagar, Maharashtra, India . 3. Assistant Professor, Department of Physiology, Jawaharlal Nehru Medical College, DMIMS (Deemed University) Wardha, India . 4. Professor, Department of Medicine, JNMC , Sawangi, Wardha, Maharashtra, India . 5. Professor, Department of Psychiatry, JNMC , Sawangi, Wardha, Maharashtra, India . 6. Private Practitioner, Gujrat . 7. Assistant Professor, Department of Biochemistry, Jawaharlal Nehru Medical College, DMIMS (Deemed University) Wardha, India .
Abstract
BACKGROUND: People are aware of the consequences of high serum lipid levels, specifically, total cholesterol. Awareness about harmful effects of very low levels of serum lipids is still lacking. Very low levels of serum lipids lead to psychological consequences. OBJECTIVES: The objective of this study was to show whether there was a significant relationship between serum lipid levels and depression. MATERIAL AND METHODS: Total 70 subjects were included in this study. 40 subjects suffering from depression as assessed with the help of clinical findings and Beck Depression Inventory (BDI) scores were included in the study group, while control group comprised of 30 normal subjects. Lipid profile was done on blood samples obtained after overnight fasting. BDI scores were also obtained in control group using BDI. Co-relation between BDI score and lipid levels was obtained in both the groups. RESULTS: Serum lipid levels were significantly low in study group as compared to control group. There was a significant negative co-relationship between serum lipid levels with depression. Subjects of study group having lower lipid levels specifically Total Cholestrol (TC) (r = -0.78), Low-Density Lipoprotein (LDL) (r = -0.69), TG (r = -0.41) and Very Low-Density Lipoprotein (VLDL)(r = - 0.418), showed higher BDI scores (p<0.05). CONCLUSION: We can conclude that there is a significant relationship between low TC and depression. Similarly, low levels of serum LDL, TG and VLDL also showed significant relationship with depression. Lipid levels below a certain limit are not good as it may cause depression. Patients with low lipid levels should be screened for depression so that if necessary, corrective measures can be taken at the earliest.
BACKGROUND:People are aware of the consequences of high serum lipid levels, specifically, total cholesterol. Awareness about harmful effects of very low levels of serum lipids is still lacking. Very low levels of serum lipids lead to psychological consequences. OBJECTIVES: The objective of this study was to show whether there was a significant relationship between serum lipid levels and depression. MATERIAL AND METHODS: Total 70 subjects were included in this study. 40 subjects suffering from depression as assessed with the help of clinical findings and Beck Depression Inventory (BDI) scores were included in the study group, while control group comprised of 30 normal subjects. Lipid profile was done on blood samples obtained after overnight fasting. BDI scores were also obtained in control group using BDI. Co-relation between BDI score and lipid levels was obtained in both the groups. RESULTS: Serum lipid levels were significantly low in study group as compared to control group. There was a significant negative co-relationship between serum lipid levels with depression. Subjects of study group having lower lipid levels specifically Total Cholestrol (TC) (r = -0.78), Low-Density Lipoprotein (LDL) (r = -0.69), TG (r = -0.41) and Very Low-Density Lipoprotein (VLDL)(r = - 0.418), showed higher BDI scores (p<0.05). CONCLUSION: We can conclude that there is a significant relationship between low TC and depression. Similarly, low levels of serum LDL, TG and VLDL also showed significant relationship with depression. Lipid levels below a certain limit are not good as it may cause depression. Patients with low lipid levels should be screened for depression so that if necessary, corrective measures can be taken at the earliest.
Authors: A W Weverling-Rijnsburger; G J Blauw; A M Lagaay; D L Knook; A E Meinders; R G Westendorp Journal: Lancet Date: 1997-10-18 Impact factor: 79.321
Authors: F M Sacks; M A Pfeffer; L A Moye; J L Rouleau; J D Rutherford; T G Cole; L Brown; J W Warnica; J M Arnold; C C Wun; B R Davis; E Braunwald Journal: N Engl J Med Date: 1996-10-03 Impact factor: 91.245
Authors: Marcela Segoviano-Mendoza; Manuel Cárdenas-de la Cruz; José Salas-Pacheco; Fernando Vázquez-Alaniz; Osmel La Llave-León; Francisco Castellanos-Juárez; Jazmín Méndez-Hernández; Marcelo Barraza-Salas; Ernesto Miranda-Morales; Oscar Arias-Carrión; Edna Méndez-Hernández Journal: BMC Psychiatry Date: 2018-01-15 Impact factor: 3.630