BACKGROUND/AIM: To determine whether higher serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is associated with longer survival of patients with breast cancer. MATERIALS AND METHODS: A meta-analysis was performed of five studies of the relationship between 25(OH)D and mortality from breast cancer. A pooled hazard ratio was calculated using a random-effects model. The Der Simonian-Laird test was used to assess homogeneity. RESULTS: Higher serum concentrations of 25(OH)D were associated with lower case-fatality rates after diagnosis of breast cancer. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest. CONCLUSION: High serum 25(OH)D was associated with lower mortality from breast cancer. Serum 25(OH)D in all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. Clinical or field studies should be initiated to confirm that this association was not due to reverse causation.
BACKGROUND/AIM: To determine whether higher serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is associated with longer survival of patients with breast cancer. MATERIALS AND METHODS: A meta-analysis was performed of five studies of the relationship between 25(OH)D and mortality from breast cancer. A pooled hazard ratio was calculated using a random-effects model. The Der Simonian-Laird test was used to assess homogeneity. RESULTS: Higher serum concentrations of 25(OH)D were associated with lower case-fatality rates after diagnosis of breast cancer. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest. CONCLUSION: High serum 25(OH)D was associated with lower mortality from breast cancer. Serum 25(OH)D in all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. Clinical or field studies should be initiated to confirm that this association was not due to reverse causation.
Entities:
Keywords:
Breast cancer; epidemiology; meta-analysis; mortality; survival; vitamin D
Authors: Tomasz Wilmanski; Alle Barnard; Mukti R Parikh; Julia Kirshner; Kimberly Buhman; John Burgess; Dorothy Teegarden Journal: Nutr Cancer Date: 2016-08-23 Impact factor: 2.900
Authors: Song Yao; Marilyn L Kwan; Isaac J Ergas; Janise M Roh; Ting-Yuan David Cheng; Chi-Chen Hong; Susan E McCann; Li Tang; Warren Davis; Song Liu; Charles P Quesenberry; Marion M Lee; Christine B Ambrosone; Lawrence H Kushi Journal: JAMA Oncol Date: 2017-03-01 Impact factor: 31.777