Literature DB >> 24596282

Transmission of nevirapine-resistant HIV type 1 via breast milk to infants after single-dose nevirapine in Beira, Mozambique.

Mark A Micek1, Sandra Dross2, Ana Judith Blanco1, Ingrid A Beck3, Laurinda Matunha4, Kristy Seidel3, Pablo Montoya1, Eduardo Matediana5, Soren Gantt2, Stephen Gloyd1, Lisa Frenkel2.   

Abstract

Acquisition of nevirapine (NVP)-resistant human immunodeficiency virus type 1 (HIV-1) by breast-feeding infants after receipt of single-dose NVP to prevent mother-to-child transmission is not well defined. A prospective observational study of 307 infants evaluated the rate of breast milk transmission of NVP-resistant HIV and the concentrations of mutants over time. NVP resistance was detected in 9 of 24 infants (37.5%; 95% confidence interval, 18.8%-59.4%) infected via breast milk. Eight had a pure mutant HIV population at the time infection was first detected, and majority mutant populations persisted in all 6 infants with follow-up specimens. Infection of breast-feeding infants with NVP-resistant HIV resulted in mutants persisting as the dominant virus, which may indefinitely compromise treatment with NVP-based antiretroviral regimens.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HIV-1; drug-resistance; mother-to-child transmission; nevirapine; zidovudine

Mesh：

Substances：

Year:  2014        PMID： 24596282      PMCID： PMC4133577          DOI： 10.1093/infdis/jiu130

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  11 in total

1.  Prolonged retention of drug resistance mutations and rapid disease progression in the absence of therapy after primary HIV infection.

Authors:  Kenny C Chan; Richard A Galli; Julio S Montaner; P Richard Harrigan
Journal:  AIDS       Date:  2003-05-23       Impact factor: 4.177

2.  Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.

Authors:  Mark A Micek; Ana Judith Blanco; Ingrid A Beck; Sandra Dross; Laurinda Matunha; Pablo Montoya; Kristy Seidel; Soren Gantt; Eduardo Matediane; Lilia Jamisse; Stephen Gloyd; Lisa M Frenkel
Journal:  Clin Infect Dis       Date:  2010-05-15       Impact factor: 9.079

3.  Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine.

Authors:  Esther J Lee; Rami Kantor; Lynn Zijenah; Wayne Sheldon; Lynda Emel; Patrick Mateta; Elizabeth Johnston; Jennifer Wells; Avinash K Shetty; Hoosen Coovadia; Yvonne Maldonado; Samuel Adeniyi Jones; Lynne M Mofenson; Christopher H Contag; Mary Bassett; David A Katzenstein
Journal:  J Infect Dis       Date:  2005-08-23       Impact factor: 5.226

4.  Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial.

Authors:  Ashraf Coovadia; Elaine J Abrams; Renate Stehlau; Tammy Meyers; Leigh Martens; Gayle Sherman; Gillian Hunt; Chih-Chi Hu; Wei-Yann Tsai; Lynn Morris; Louise Kuhn
Journal:  JAMA       Date:  2010-09-08       Impact factor: 56.272

5.  Antiretroviral-drug resistance among patients recently infected with HIV.

Authors:  Susan J Little; Sarah Holte; Jean-Pierre Routy; Eric S Daar; Marty Markowitz; Ann C Collier; Richard A Koup; John W Mellors; Elizabeth Connick; Brian Conway; Michael Kilby; Lei Wang; Jeannette M Whitcomb; Nicholas S Hellmann; Douglas D Richman
Journal:  N Engl J Med       Date:  2002-08-08       Impact factor: 91.245

6.  Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).

Authors:  S H Eshleman; M Mracna; L A Guay; M Deseyve; S Cunningham; M Mirochnick; P Musoke; T Fleming; M Glenn Fowler; L M Mofenson; F Mmiro; J B Jackson
Journal:  AIDS       Date:  2001-10-19       Impact factor: 4.177

7.  Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-Dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission.

Authors:  Jessica D Church; Saad B Omer; Laura A Guay; Wei Huang; Jessica Lidstrom; Philippa Musoke; Francis Mmiro; J Brooks Jackson; Susan H Eshleman
Journal:  J Infect Dis       Date:  2008-10-01       Impact factor: 5.226

8.  HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis.

Authors:  Clement Zeh; Paul J Weidle; Lillian Nafisa; Humphrey M Lwamba; Jully Okonji; Emily Anyango; Philip Bondo; Rose Masaba; Mary Glenn Fowler; John N Nkengasong; Michael C Thigpen; Timothy Thomas
Journal:  PLoS Med       Date:  2011-03-29       Impact factor: 11.069

9.  Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis.

Authors:  Ravindra K Gupta; Michael R Jordan; Binta J Sultan; Andrew Hill; Daniel H J Davis; John Gregson; Anthony W Sawyer; Raph L Hamers; Nicaise Ndembi; Deenan Pillay; Silvia Bertagnolio
Journal:  Lancet       Date:  2012-07-23       Impact factor: 79.321

10.  Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants.

Authors:  Anitha Moorthy; Amita Gupta; Ramesh Bhosale; Srikanth Tripathy; Jayagowri Sastry; Smita Kulkarni; Madhuri Thakar; Renu Bharadwaj; Anju Kagal; Arvind V Bhore; Sandesh Patil; Vandana Kulkarni; Varadharajan Venkataramani; Usha Balasubramaniam; Nishi Suryavanshi; Carrie Ziemniak; Nikhil Gupte; Robert Bollinger; Deborah Persaud
Journal:  PLoS One       Date:  2009-01-01       Impact factor: 3.240
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  7 in total

1.  Persistence of HIV drug resistance among South African children given nevirapine to prevent mother-to-child-transmission.

Authors:  Ruth Kanthula; Theresa M Rossouw; Ute D Feucht; Gisela van Dyk; Ingrid A Beck; Rachel Silverman; Scott Olson; Christen Salyer; Sharon Cassol; Lisa M Frenkel
Journal:  AIDS       Date:  2017-05-15       Impact factor: 4.177

2.  Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk.

Authors:  Joshua Gini; Sujan Dilly Penchala; Alieu Amara; Elizabeth Challenger; Deirdre Egan; Catriona Waitt; Mohammed Lamorde; Catherine Orrell; Landon Myer; Saye Khoo; Laura J Else
Journal:  Bioanalysis       Date:  2018-11-19       Impact factor: 2.681

3.  Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study.

Authors:  Adeniyi Olagunju; Oluseye Bolaji; Alieu Amara; Catriona Waitt; Laura Else; Ebunoluwa Adejuyigbe; Marco Siccardi; David Back; Saye Khoo; Andrew Owen
Journal:  Clin Infect Dis       Date:  2015-04-16       Impact factor: 9.079

4.  Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.

Authors:  Francisco Antunes; Pereira Zindoga; Perpétua Gomes; Orvalho Augusto; Isabel Mahumane; Luís Veloso; Emília Valadas; Ricardo Camacho
Journal:  PLoS One       Date:  2015-07-10       Impact factor: 3.240

5.  A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission.

Authors:  Reshmi Samuel; Roger Paredes; Raveen Parboosing; Pravi Moodley; Lavanya Singh; Anneta Naidoo; Michelle Gordon
Journal:  J Med Virol       Date:  2015-05-04       Impact factor: 2.327

6.  Nevirapine hair and plasma concentrations and HIV-1 viral suppression among HIV infected ante-partum and post-partum women attended in a mother and child prevention program in Maputo city, Mozambique.

Authors:  Rosa Marlene Cuco; Osvaldo Loquiha; Adelino Juga; Aleny Couto; Bindiya Meggi; Adolfo Vubil; Esperança Sevene; Nafissa Osman; Marleen Temermam; Olivier Degomme; Mohsin Sidat; Nilesh Bhatt
Journal:  PLoS One       Date:  2022-02-10       Impact factor: 3.240

7.  HIV drug resistance patterns in pregnant women using next generation sequence in Mozambique.

Authors:  María Rupérez; Marc Noguera-Julian; Raquel González; Sonia Maculuve; Rocío Bellido; Anifa Vala; Cristina Rodríguez; Esperança Sevene; Roger Paredes; Clara Menéndez
Journal:  PLoS One       Date:  2018-05-09       Impact factor: 3.240
  7 in total

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