OBJECTIVE: In view of the mild effects of pharmacological treatment for dementia due to Alzheimer's disease (AD), the search for modifiable risk factors is an important challenge. Although risk factors for AD are widely recognized, elements that influence the time of onset of the dementia syndrome have not been comprehensively reported. We aimed to investigate which risk factors might be associated with the age at onset of AD in a sample of patients with low mean schooling from São Paulo, Brazil. METHODS: We included 210 consecutive patients with late-onset AD to investigate whether education, gender, nationality, urban living and sanitation, occupation, cognitive and physical inactivity, head trauma, depression, systemic infections, surgical interventions, cerebrovascular risk factors, family history of neurodegenerative diseases or cardiovascular diseases and apolipoprotein E gene (APOE) haplotypes might be related to the age at AD onset. RESULTS: Each copy of APOE-ε4 led to onset of AD almost 2 years earlier, while depression, smoking, higher body mass index and family history of cardiovascular diseases were also highly significant. Protective factors included non-Brazilian nationality, use of a pacemaker and waist circumference. Cerebrovascular risk factors had a mild combined effect for earlier onset of AD. CONCLUSION: APOE haplotypes, depression, nationality and cerebrovascular risk factors were the most important elements to influence the age at AD onset in this sample, whereas gender, education, occupation and physical activities had no isolated effects over the age at onset of this dementia syndrome.
OBJECTIVE: In view of the mild effects of pharmacological treatment for dementia due to Alzheimer's disease (AD), the search for modifiable risk factors is an important challenge. Although risk factors for AD are widely recognized, elements that influence the time of onset of the dementia syndrome have not been comprehensively reported. We aimed to investigate which risk factors might be associated with the age at onset of AD in a sample of patients with low mean schooling from São Paulo, Brazil. METHODS: We included 210 consecutive patients with late-onset AD to investigate whether education, gender, nationality, urban living and sanitation, occupation, cognitive and physical inactivity, head trauma, depression, systemic infections, surgical interventions, cerebrovascular risk factors, family history of neurodegenerative diseases or cardiovascular diseases and apolipoprotein E gene (APOE) haplotypes might be related to the age at AD onset. RESULTS: Each copy of APOE-ε4 led to onset of AD almost 2 years earlier, while depression, smoking, higher body mass index and family history of cardiovascular diseases were also highly significant. Protective factors included non-Brazilian nationality, use of a pacemaker and waist circumference. Cerebrovascular risk factors had a mild combined effect for earlier onset of AD. CONCLUSION:APOE haplotypes, depression, nationality and cerebrovascular risk factors were the most important elements to influence the age at AD onset in this sample, whereas gender, education, occupation and physical activities had no isolated effects over the age at onset of this dementia syndrome.
Authors: Fabricio F de Oliveira; Elizabeth S Chen; Marilia C Smith; Paulo H Bertolucci Journal: Braz J Psychiatry Date: 2017-01-12 Impact factor: 2.697
Authors: Mario Alfredo Parra; Sandra Baez; Lucas Sedeño; Cecilia Gonzalez Campo; Hernando Santamaría-García; Ivan Aprahamian; Paulo Hf Bertolucci; Julian Bustin; Maria Aparecida Camargos Bicalho; Carlos Cano-Gutierrez; Paulo Caramelli; Marcia L F Chaves; Patricia Cogram; Bárbara Costa Beber; Felipe A Court; Leonardo Cruz de Souza; Nilton Custodio; Andres Damian; Myriam de la Cruz; Roberta Diehl Rodriguez; Sonia Maria Dozzi Brucki; Lais Fajersztajn; Gonzalo A Farías; Fernanda G De Felice; Raffaele Ferrari; Fabricio Ferreira de Oliveira; Sergio T Ferreira; Ceres Ferretti; Marcio Luiz Figueredo Balthazar; Norberto Anizio Ferreira Frota; Patricio Fuentes; Adolfo M García; Patricia J Garcia; Fábio Henrique de Gobbi Porto; Lissette Duque Peñailillo; Henry Willy Engler; Irene Maier; Ignacio F Mata; Christian Gonzalez-Billault; Oscar L Lopez; Laura Morelli; Ricardo Nitrini; Yakeel T Quiroz; Alejandra Guerrero Barragan; David Huepe; Fabricio Joao Pio; Claudia Kimie Suemoto; Renata Kochhann; Silvia Kochen; Fiona Kumfor; Serggio Lanata; Bruce Miller; Leticia Lessa Mansur; Mirna Lie Hosogi; Patricia Lillo; Jorge Llibre Guerra; David Lira; Francisco Lopera; Adelina Comas; José Alberto Avila-Funes; Ana Luisa Sosa; Claudia Ramos; Elisa de Paula França Resende; Heather M Snyder; Ioannis Tarnanas; Jenifer Yokoyama; Juan Llibre; Juan Felipe Cardona; Kate Possin; Kenneth S Kosik; Rosa Montesinos; Sebastian Moguilner; Patricia Cristina Lourdes Solis; Renata Eloah de Lucena Ferretti-Rebustini; Jeronimo Martin Ramirez; Diana Matallana; Lingani Mbakile-Mahlanza; Alyne Mendonça Marques Ton; Ronnielly Melo Tavares; Eliane C Miotto; Graciela Muniz-Terrera; Luis Arnoldo Muñoz-Nevárez; David Orozco; Maira Okada de Oliveira; Olivier Piguet; Maritza Pintado Caipa; Stefanie Danielle Piña Escudero; Lucas Porcello Schilling; André Luiz Rodrigues Palmeira; Mônica Sanches Yassuda; Jose Manuel Santacruz-Escudero; Rodrigo Bernardo Serafim; Jerusa Smid; Andrea Slachevsky; Cecilia Serrano; Marcio Soto-Añari; Leonel Tadao Takada; Lea Tenenholz Grinberg; Antonio Lucio Teixeira; Maira Tonidandel Barbosa; Dominic Trépel; Agustin Ibanez Journal: Alzheimers Dement Date: 2020-11-20 Impact factor: 21.566
Authors: Nárlon C Boa Sorte Silva; Oliver Bracko; Amy R Nelson; Fabricio Ferreira de Oliveira; Lisa S Robison; C Elizabeth Shaaban; Atticus H Hainsworth; Brittani R Price Journal: Alzheimers Dement (Amst) Date: 2022-04-27
Authors: Fabricio Ferreira de Oliveira; Juliana Marília Berretta; Guido Veiga de Almeida Junior; Sandro Soares de Almeida; Elizabeth Suchi Chen; Marilia Cardoso Smith; Paulo Henrique Ferreira Bertolucci Journal: Indian J Med Res Date: 2019-09 Impact factor: 2.375