Literature DB >> 2459519

Threshold phenomena and interactions between receptors.

N A Flavahan1, P M Vanhoutte.   

Abstract

Threshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro.

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Year:  1988        PMID： 2459519

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  3 in total

1.  Acute activation of endothelial AMPK surprisingly inhibits endothelium-dependent hyperpolarization-like relaxations in rat mesenteric arteries.

Authors:  Hui Chen; Paul M Vanhoutte; Susan W S Leung
Journal:  Br J Pharmacol       Date:  2019-07-04       Impact factor: 8.739

2.  Modulation of vascular function by neuropeptide Y during development of hypertension in spontaneously hypertensive rats.

Authors:  Z Zukowska-Grojec; M Golczynska; G H Shen; A Torres-Duarte; M Haass; C Wahlestedt; A K Myers
Journal:  Pediatr Nephrol       Date:  1993-12       Impact factor: 3.714

3.  Potentiation by endothelin-1 of 5-hydroxytryptamine responses in aortae from streptozotocin-diabetic rats: a role for thromboxane A2.

Authors:  G M James; W C Hodgson
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739
  3 in total

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