Literature DB >> 2459505

Functional expression of the amplification reaction between serotonin and epinephrine on platelets.

F De Clerck1, B Xhonneux, D de Chaffoy de Courcelles.   

Abstract

Human platelet reactions are enhanced when a combination of serotonin and epinephrine is used as a stimulus. The amplification of the response operates through S2-serotonergic and alpha 2-adrenergic receptor subtypes. The first wave of platelet aggregation, which is independent of platelet release products, is enhanced while the latency period for the occurrence of release reaction and prostaglandin biosynthesis is shortened. Synergism between serotonin and epinephrine on the platelet occurs at low concentration of agonists and may contribute to the formation of an arterial thrombus in vivo.

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Year:  1988        PMID： 2459505

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  6 in total

1.  Interaction between the effects of 5-hydroxytryptamine and adrenaline on the growth of platelet thrombi in the coronary artery of the anaesthetized dog.

Authors:  S J McAuliffe; H M Snow; B Cox; C C Smith; M I Noble
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

Review 2.  The role of serotonin in cardiovascular diseases and their treatment.

Authors:  P A van Zwieten; G J Blauw; P van Brummelen
Journal:  Cardiovasc Drugs Ther       Date:  1990-12       Impact factor: 3.727

3.  The potentiation of adrenaline-induced in vitro platelet aggregation by ADP, collagen and serotonin and its inhibition by naftopidil and doxazosin in normal human subjects.

Authors:  N A Alarayyed; B R Graham; B N Prichard; C C Smith
Journal:  Br J Clin Pharmacol       Date:  1995-04       Impact factor: 4.335

4.  Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers.

Authors:  Kirstin Aschbacher; Susan K Roepke; Roland von Känel; Paul J Mills; Brent T Mausbach; Thomas L Patterson; Joel E Dimsdale; Michael G Ziegler; Sonia Ancoli-Israel; Igor Grant
Journal:  J Affect Disord       Date:  2009-01-08       Impact factor: 4.839

5.  Naftopidil inhibits 5-hydroxytryptamine-induced platelet aggregation and 5-hydroxytryptamine uptake in platelets of healthy volunteers.

Authors:  R Kirsten; M Breidert; K Nelson; A Heine; S Rosenkranz; B Erdeg; G Niebch; H O Borbe; M Siebert-Weigel; J Respondek
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

6.  Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers.

Authors:  Kirstin Aschbacher; Paul J Mills; Roland von Känel; Suzi Hong; Brent T Mausbach; Susan K Roepke; Joel E Dimsdale; Thomas L Patterson; Michael G Ziegler; Sonia Ancoli-Israel; Igor Grant
Journal:  Brain Behav Immun       Date:  2007-11-28       Impact factor: 7.217
  6 in total

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