Literature DB >> 24595040

Hypertension: is the sham procedure 'toxic' for renal denervation?

Costas Tsioufis1.   

Abstract

The announcement by Medtronic that the SYMPLICITY HTN-3 trial failed to meet its primary effectiveness end point calls the blood pressure lowering effects of renal denervation into question. However, its safety is proven, which raises the possibility that the procedure might have beneficial effects on the kidneys beyond blood pressure reduction.

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Year:  2014        PMID: 24595040     DOI: 10.1038/nrneph.2014.28

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN: 1759-5061            Impact factor:   28.314


  8 in total

1.  Randomised trial of treatment of hypertension in elderly patients in primary care.

Authors:  J Coope; T S Warrender
Journal:  Br Med J (Clin Res Ed)       Date:  1986-11-01

2.  Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial.

Authors:  Murray D Esler; Henry Krum; Paul A Sobotka; Markus P Schlaich; Roland E Schmieder; Michael Böhm
Journal:  Lancet       Date:  2010-11-17       Impact factor: 79.321

Review 3.  The role of sympathetic nervous system in the progression of chronic kidney disease in the era of catheter based sympathetic renal denervation.

Authors:  Dimitrios Petras; Konstantinos Koutroutsos; Athanasios Kordalis; Costas Tsioufis; Christodoulos Stefanadis
Journal:  Curr Clin Pharmacol       Date:  2013-08

4.  Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial.

Authors:  Murray D Esler; Henry Krum; Markus Schlaich; Roland E Schmieder; Michael Böhm; Paul A Sobotka
Journal:  Circulation       Date:  2012-12-18       Impact factor: 29.690

5.  Hypotensive therapy in stroke survivors.

Authors:  A B Carter
Journal:  Lancet       Date:  1970-03-07       Impact factor: 79.321

6.  Refractory hypertension: determination of prevalence, risk factors, and comorbidities in a large, population-based cohort.

Authors:  David A Calhoun; John N Booth; Suzanne Oparil; Marguerite R Irvin; Daichi Shimbo; Daniel T Lackland; George Howard; Monika M Safford; Paul Muntner
Journal:  Hypertension       Date:  2013-12-09       Impact factor: 10.190

7.  Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 Trial.

Authors:  David E Kandzari; Deepak L Bhatt; Paul A Sobotka; William W O'Neill; Murray Esler; John M Flack; Barry T Katzen; Martin B Leon; Joseph M Massaro; Manuela Negoita; Suzanne Oparil; Krishna Rocha-Singh; Craig Straley; Raymond R Townsend; George Bakris
Journal:  Clin Cardiol       Date:  2012-05-09       Impact factor: 2.882

8.  Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial.

Authors:  Stephen G Worthley; Costas P Tsioufis; Matthew I Worthley; Ajay Sinhal; Derek P Chew; Ian T Meredith; Yuvi Malaiapan; Vasilios Papademetriou
Journal:  Eur Heart J       Date:  2013-06-19       Impact factor: 29.983

  8 in total

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