Ken-Ichiro Yamashita1, Yoshihide Taniwaki2, Hidetsuna Utsunomiya3, Takayuki Taniwaki1. 1. Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan. 2. Department of Neurology, Fukuoka Sanno Hospital, Fukuoka, Japan. 3. Department of Radiology, Fukuoka Sanno Hospital, Fukuoka, Japan.
Abstract
BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. AD patients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in AD patients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.
BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. ADpatients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in ADpatients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.
Authors: Inés López-Cuenca; Elena Salobrar-García; Lidia Sánchez-Puebla; Eva Espejel; Lucía García Del Arco; Pilar Rojas; Lorena Elvira-Hurtado; José A Fernández-Albarral; Federico Ramírez-Toraño; Ana Barabash; Juan J Salazar; José M Ramírez; Rosa de Hoz; Ana I Ramírez Journal: J Clin Med Date: 2022-06-06 Impact factor: 4.964
Authors: Chiara Criscuolo; Gilda Cennamo; Daniela Montorio; Antonio Carotenuto; Alfonso Strianese; Elena Salvatore; Fausto Tranfa; Giovanni Cennamo; Roberta Lanzillo; Vincenzo Brescia Morra Journal: PLoS One Date: 2020-06-03 Impact factor: 3.240