Literature DB >> 24593224

Metabolites of antroquinonol found in rat urine following oral administration.

Chien-Kuang Chen1, Jaw-Jou Kang, Wu-Che Wen, Hui-Fen Chiang, Shoei-Sheng Lee.   

Abstract

Four metabolites (1-4) of antroquinonol from rat urine, collected within 24 h after oral administration of antroquinonol, were characterized by HPLC-SPE-NMR. Compounds 1-4 were further isolated by semipreparative HPLC for structure confirmation. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and HRESIMS data.

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Year:  2014        PMID: 24593224     DOI: 10.1021/np400670a

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  1 in total

1.  Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate.

Authors:  Matthew T Villaume; Eran Sella; Garrett Saul; Robert M Borzilleri; Joseph Fargnoli; Kathy A Johnston; Haiying Zhang; Mark P Fereshteh; T G Murali Dhar; Phil S Baran
Journal:  ACS Cent Sci       Date:  2015-12-23       Impact factor: 14.553

  1 in total

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