| Literature DB >> 24593120 |
Qi-Bin Chen1, Xue-Lei Xin, Yi Yang, Shoei-Sheng Lee, H A Aisa.
Abstract
Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 μM.Entities:
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Year: 2014 PMID： 24593120 DOI： 10.1021/np4009078
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050