Nilüfer Çetinkaya Kocadal1, Rukset Attar1, Gazi Yıldırım1, Cem Fıçıcıoğlu1, Ferda Ozkan2, Bayram Yılmaz3, Narter Yesildaglar1. 1. Department of Obstetrics and Gynecology, Yeditepe University School of Medicine, İstanbul, Turkey. 2. Department of Pathology, Yeditepe University School of Medicine, İstanbul, Turkey. 3. Department of Physiology and Experimental Studies and Research Center, Yeditepe University School of Medicine, İstanbul, Turkey.
Abstract
OBJECTIVE: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model. MATERIAL AND METHODS: This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined. RESULTS: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. CONCLUSION: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.
OBJECTIVE: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized ratendometriosis model. MATERIAL AND METHODS: This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined. RESULTS: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly. CONCLUSION:Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.
Authors: Ali Yavuzcan; Mete Cağlar; Yusuf Ustün; Serdar Dilbaz; Ismail Ozdemir; Elif Yıldız; Atilla Ozkara; Selahattin Kumru Journal: J Turk Ger Gynecol Assoc Date: 2013-12-01