Nalan Cihangir1, Hüzeyin Görkemli1, Suna Ozdemir1, Murat Aktan2, Selçuk Duman2. 1. Department of Obstetrics and Gynecology, Meram Medical Faculty, Selcuk University, Konya, Turkey. 2. Department of Histology and Embryolog, Meram Medical Faculty, Selcuk University, Konya, Turkey.
Abstract
OBJECTIVE: In this study, we aimed to evaluate the influence of autologous cumulus oocyte complex (COC) coculture on embryonic development and quality, and investigate the implantation and pregnancy rates after cumulus-aided embryo transfer in the ICSI-ET cycles. MATERIAL AND METHODS: Ninety five consecutive infertile women undergoing their first cycle of IVF teratment were included in the study. The cases were divided into two groups. Group 1 consisted of 48 women undergoing ICSI, along with autologous cumulus embryo coculture and cumulus-aided emryo transfer. Group 2 comprised 47 consecutive patients who consented to undergo ICSI and in whom autologous cumulus embryo coculture and cumulus-aided embryo transfer were not performed. Implantation and pregnancy rates were compared between the two groups. RESULTS: The demographic data and controlled ovarian hyperstimulation parameters were similar in the two groups. The fertilization and cleavage rates were found to be higher in group 1 when compared with group 2 (p=0.03 and 0.001, respectively). There were no statistical significant differences for the implantation and clinical pregnancy rates between the two groups. CONCLUSION: Usage of autologous COCs as coculture may improve fertilization and cleavage rates. However, cumulus-aided embryo transfer does not produce an increase in implantation and pregnancy rates.
OBJECTIVE: In this study, we aimed to evaluate the influence of autologous cumulus oocyte complex (COC) coculture on embryonic development and quality, and investigate the implantation and pregnancy rates after cumulus-aided embryo transfer in the ICSI-ET cycles. MATERIAL AND METHODS: Ninety five consecutive infertile women undergoing their first cycle of IVF teratment were included in the study. The cases were divided into two groups. Group 1 consisted of 48 women undergoing ICSI, along with autologous cumulus embryo coculture and cumulus-aided emryo transfer. Group 2 comprised 47 consecutive patients who consented to undergo ICSI and in whom autologous cumulus embryo coculture and cumulus-aided embryo transfer were not performed. Implantation and pregnancy rates were compared between the two groups. RESULTS: The demographic data and controlled ovarian hyperstimulation parameters were similar in the two groups. The fertilization and cleavage rates were found to be higher in group 1 when compared with group 2 (p=0.03 and 0.001, respectively). There were no statistical significant differences for the implantation and clinical pregnancy rates between the two groups. CONCLUSION: Usage of autologous COCs as coculture may improve fertilization and cleavage rates. However, cumulus-aided embryo transfer does not produce an increase in implantation and pregnancy rates.
Authors: C Simón; A Mercader; J Garcia-Velasco; G Nikas; C Moreno; J Remohí; A Pellicer Journal: J Clin Endocrinol Metab Date: 1999-08 Impact factor: 5.958
Authors: Tahsin Murad Aktan; Hüseyin Görkemli; Kazım Gezginç; Aslı Saylan; Selçuk Duman; Fatma Yazıcı Yılmaz Journal: J Turk Ger Gynecol Assoc Date: 2011-09-01
Authors: Harsha K Bhadarka; Nayana H Patel; Niket H Patel; Molina Patel; Kruti B Patel; Nilofar R Sodagar; Ajay G Phatak; Jagdish S Patel Journal: Indian J Med Res Date: 2017-09 Impact factor: 2.375