OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score. RESULTS: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes (p=0.11), 68% and 86% in eyes with previous ON (p=0.12), and in 19% versus 40% in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, p<0.001) and with EDSS (RNFL: ρ=0.40, p<0.001; VEP score: ρ=0.47, p<0.001). Disease duration correlated with VEP score (ρ=0.25, p=0.025) and RNFL thickness (ρ=-0.71, p<0.001). CONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.
OBJECTIVE: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). METHODS: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0-4 conventional score. RESULTS: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes (p=0.11), 68% and 86% in eyes with previous ON (p=0.12), and in 19% versus 40% in eyes without ON history (p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=-0.63, p<0.001) and with EDSS (RNFL: ρ=0.40, p<0.001; VEP score: ρ=0.47, p<0.001). Disease duration correlated with VEP score (ρ=0.25, p=0.025) and RNFL thickness (ρ=-0.71, p<0.001). CONCLUSIONS: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.
Authors: Moones Heidari; Abigail B Radcliff; Gillian J McLellan; James N Ver Hoeve; Kore Chan; Julie A Kiland; Nicholas S Keuler; Benjamin K August; Dylan Sebo; Aaron S Field; Ian D Duncan Journal: Proc Natl Acad Sci U S A Date: 2019-12-16 Impact factor: 11.205
Authors: Mona Laible; Sven Jarius; Friedericke Mackensen; Annette Schmidt-Bacher; Michael Platten; Jürgen Haas; Philipp Albrecht; Brigitte Wildemann Journal: PLoS One Date: 2016-05-12 Impact factor: 3.240
Authors: Amy T Waldman; Grant T Liu; Amy M Lavery; Geraldine Liu; William Gaetz; Tomas S Aleman; Brenda L Banwell Journal: Neurol Neuroimmunol Neuroinflamm Date: 2017-06-05
Authors: Rachel C Nolan; Steven L Galetta; Teresa C Frohman; Elliot M Frohman; Peter A Calabresi; Carmen Castrillo-Viguera; Diego Cadavid; Laura J Balcer Journal: J Neuroophthalmol Date: 2018-12 Impact factor: 3.042
Authors: Steven L Galetta; Pablo Villoslada; Netta Levin; Kenneth Shindler; Hiroshi Ishikawa; Edward Parr; Diego Cadavid; Laura J Balcer Journal: Neurol Neuroimmunol Neuroinflamm Date: 2015-07-23
Authors: Felix A Schmidt; Florian Connolly; Matthew B Maas; Ulrike Grittner; Lutz Harms; Alexander Brandt; Friedemann Paul; Stephan Schreiber; Klemens Ruprecht Journal: PLoS One Date: 2018-08-27 Impact factor: 3.240