| Literature DB >> 24591104 |
Roberta Ricciarelli1, Daniela Puzzo, Olga Bruno, Elisa Canepa, Elena Gardella, Daniela Rivera, Lucia Privitera, Cinzia Domenicotti, Barbara Marengo, Umberto Maria Marinari, Agostino Palmeri, Maria Adelaide Pronzato, Ottavio Arancio, Ernesto Fedele.
Abstract
Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aβ production.Entities:
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Year: 2014 PMID： 24591104 DOI： 10.1002/ana.24130
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422