Literature DB >> 24590483

Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling.

Malene Winther1, Michael Gabl, Tudor I Oprea, Bodil Jönsson, Francois Boulay, Johan Bylund, Claes Dahlgren, Huamei Forsman.   

Abstract

Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.

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Year:  2014        PMID： 24590483      PMCID： PMC3993206          DOI： 10.1128/AAC.02716-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides.

Authors:  Lidija Covic; Amy L Gresser; Joyce Talavera; Steven Swift; Athan Kuliopulos
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

2.  Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori.

Authors:  J Bylund; T Christophe; F Boulay; T Nyström; A Karlsson; C Dahlgren
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 3.  Ligand recognition and activation of formyl peptide receptors in neutrophils.

Authors:  Huamei Fu; Jennie Karlsson; Johan Bylund; Charlotta Movitz; Anna Karlsson; Claes Dahlgren
Journal:  J Leukoc Biol       Date:  2005-12-19       Impact factor: 4.962

4.  Measurement of respiratory burst products, released or retained, during activation of professional phagocytes.

Authors:  Johan Bylund; Halla Björnsdottir; Martina Sundqvist; Anna Karlsson; Claes Dahlgren
Journal:  Methods Mol Biol       Date:  2014

Review 5.  The molecular biology of leukocyte chemoattractant receptors.

Authors:  P M Murphy
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

6.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

7.  Interactions of the antimicrobial peptide Ac-FRWWHR-NH(2) with model membrane systems and bacterial cells.

Authors:  A J Rezansoff; H N Hunter; W Jing; I Y Park; S C Kim; H J Vogel
Journal:  J Pept Res       Date:  2005-05

Review 8.  Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections.

Authors:  Yechiel Shai; Arik Makovitzky; Dorit Avrahami
Journal:  Curr Protein Pept Sci       Date:  2006-12       Impact factor: 3.272

9.  LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.

Authors:  Q Chen; A P Schmidt; G M Anderson; J M Wang; J Wooters; J J Oppenheim; O Chertov
Journal:  J Exp Med       Date:  2000-10-02       Impact factor: 14.307

10.  Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia.

Authors:  D Hultmark; A Engström; K Andersson; H Steiner; H Bennich; H G Boman
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  4 in total

Review 1.  Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions.

Authors:  Claes Dahlgren; André Holdfeldt; Simon Lind; Jonas Mårtensson; Michael Gabl; Lena Björkman; Martina Sundqvist; Huamei Forsman
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-11

2.  Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.

Authors:  Ping Zhang; Lidija Covic; Athan Kuliopulos
Journal:  Methods Mol Biol       Date:  2015

3.  Lipopeptide Pepducins as Therapeutic Agents.

Authors:  Emily Michael; Lidija Covic; Athan Kuliopulos
Journal:  Methods Mol Biol       Date:  2022

4.  Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question.

Authors:  Malene Winther; André Holdfeldt; Martina Sundqvist; Zahra Rajabkhani; Michael Gabl; Johan Bylund; Claes Dahlgren; Huamei Forsman
Journal:  PLoS One       Date:  2017-09-21       Impact factor: 3.240
  4 in total

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