| Literature DB >> 24590476 |
J S De Araújo1, C F Da Silva1, D G J Batista1, P B Da Silva1, M B Meuser1, C A F Aiub2, M F V da Silva2, C F Araújo-Lima3, M Banerjee4, A A Farahat5, C E Stephens6, A Kumar4, D W Boykin4, M N C Soeiro7.
Abstract
Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.Entities:
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Year: 2014 PMID： 24590476 PMCID： PMC4068551 DOI： 10.1128/AAC.01403-13
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191