Literature DB >> 2459034

Pharmacokinetics of 125I-hirudin in rats and dogs.

M Richter1, U Cyranka, G Nowak, P Walsmann.   

Abstract

Hirudin was 125I-labelled using a modified chloramine-T method. 125I-hirudin proved to be a suitable marker in pharmacokinetic studies, if unchanged 125I-hirudin in body fluids was determined by means of a binding assay using immobilized thrombin. In rats and dogs a study was performed on the pharmacokinetic behaviour of hirudin following intravenous and subcutaneous injection, resp., or one-hour infusion and pharmacokinetic parameters were calculated.

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Year:  1988        PMID： 2459034

Source DB:  PubMed          Journal:  Folia Haematol Int Mag Klin Morphol Blutforsch        ISSN： 0323-4347


  4 in total

1.  Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent.

Authors:  Ruchika Sharma; Amanda P Waller; Shipra Agrawal; Katelyn J Wolfgang; Hiep Luu; Khurrum Shahzad; Berend Isermann; William E Smoyer; Marvin T Nieman; Bryce A Kerlin
Journal:  J Am Soc Nephrol       Date:  2017-04-19       Impact factor: 10.121

2.  Catabolism of hirudin and thrombin-hirudin complexes in the rat.

Authors:  J Bichler; J W Baynes; S R Thorpe
Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857

3.  Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays.

Authors:  Su-Yun Jiang; Jian Jiao; Ting-Ting Zhang; Yong-Ping Xu
Journal:  PLoS One       Date:  2013-06-13       Impact factor: 3.240

Review 4.  Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review.

Authors:  Chen Junren; Xie Xiaofang; Zhang Huiqiong; Li Gangmin; Yin Yanpeng; Cao Xiaoyu; Gao Yuqing; Li Yanan; Zhang Yue; Peng Fu; Peng Cheng
Journal:  Front Pharmacol       Date:  2021-04-16       Impact factor: 5.810
  4 in total

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