Fibrin glue on the Cohn I fraction basis in repairing cerebral and dura defects--an experimental study on rats.

The rat skulls were operated upon using a trephine osteoplastically, and a defined cerebral and dura defect was induced. The repair of the cerebral defect was performed with Cohn I glue, or in combination with collageneous fleece. The dura defect was repaired by suture and/or glueing of a split skin or pedicle galeal-periostal flap. Thanks to using Cohn I glue, at all times sufficient venous hemostasis could be achieved, and in combination with collagen fleece the repair was at an optimum. The histological check-up demonstrated that neurotoxic side-effects were absent and there were no conglutinations with the dura. Suturing of the dura was highly time-consuming and impossible when the dura had been removed near the bone. The use of Cohn I adhesive permitted ready and defect repair commonly applicable. At high tension the combined suture-glueing technique proved to be superior.