Erol Tülümen1, Carla Giustetto2, Christian Wolpert3, Philippe Maury4, Olli Anttonen5, Vincent Probst6, Jean-Jacques Blanc7, Pascal Sbragia8, Chiara Scrocco8, Boris Rudic9, Christian Veltmann9, Yaxun Sun10, Fiorenzo Gaita2, Charles Antzelevitch11, Martin Borggrefe9, Rainer Schimpf9. 1. University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany. Electronic address: erol.tueluemen@umm.de. 2. Division of Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy. 3. Department of Medicine-Cardiology, Nephrology and Internal Intensive Care Medicine, Klinikum Ludwigsburg, Ludwigsburg, Germany. 4. Federation of Cardiology, University Hospital Rangueil, Toulouse, France. 5. Division of Cardiology, Lahti Central Hospital, Lahti, Finland. 6. Service de Cardiologie, Institut du Thorax, Université de Nantes, Nantes, France. 7. Departement de Cardiologie, Université de Bretagne Occidentale, Hôpital de la Cavale Blanche, Brest, France. 8. Division of Cardiology, Hôpital Nord, Marseille, France. 9. University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany. 10. Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. 11. Masonic Medical Research Laboratory, Utica, New York.
Abstract
BACKGROUND: Patients with short QT syndrome (SQTS) have an increased risk for atrial tachyarrhythmias, ventricular tachyarrhythmias, and/or sudden cardiac death. PQ segment depression (PQD) is related to atrial fibrillation and carries a poor prognosis in the setting of acute inferior myocardial infarction and is a well-defined electrocardiographic (ECG) marker of acute pericarditis. OBJECTIVE: To evaluate the prevalence of PQD in SQTS and to analyze the association with atrial arrhythmias. METHODS: Digitalized 12-lead ECGs of SQTS patients were evaluated for PQD in all leads and for QT intervals in leads II and V5. PQD was defined as ≥0.05 mV (0.5 mm) depression from the isoelectric line. RESULTS: A total of 760 leads from 64 SQTS patients (mean age 36 ± 18 years; 48 [75%] men) were analyzed. PQD was seen in 265 (35%) leads from 52 (81%) patients and was more frequent in leads II, V3, aVF, V4, and I (n = 43 [67%], n = 30 [47%], n = 27 [42%], n = 25 [39%], and n = 25 [39%], respectively). Nine of 64 (14%) patients presented with atrial tachyarrhythmias, and all of them had PQD. CONCLUSION: Fifty-two of 64 (81%) patients with SQTS reveal PQD. As PQD is rarely observed in healthy individuals, this ECG stigma may constitute a novel marker for SQTS in addition to a short QT interval.
BACKGROUND:Patients with short QT syndrome (SQTS) have an increased risk for atrial tachyarrhythmias, ventricular tachyarrhythmias, and/or sudden cardiac death. PQ segment depression (PQD) is related to atrial fibrillation and carries a poor prognosis in the setting of acute inferior myocardial infarction and is a well-defined electrocardiographic (ECG) marker of acute pericarditis. OBJECTIVE: To evaluate the prevalence of PQD in SQTS and to analyze the association with atrial arrhythmias. METHODS: Digitalized 12-lead ECGs of SQTS patients were evaluated for PQD in all leads and for QT intervals in leads II and V5. PQD was defined as ≥0.05 mV (0.5 mm) depression from the isoelectric line. RESULTS: A total of 760 leads from 64 SQTS patients (mean age 36 ± 18 years; 48 [75%] men) were analyzed. PQD was seen in 265 (35%) leads from 52 (81%) patients and was more frequent in leads II, V3, aVF, V4, and I (n = 43 [67%], n = 30 [47%], n = 27 [42%], n = 25 [39%], and n = 25 [39%], respectively). Nine of 64 (14%) patients presented with atrial tachyarrhythmias, and all of them had PQD. CONCLUSION: Fifty-two of 64 (81%) patients with SQTS reveal PQD. As PQD is rarely observed in healthy individuals, this ECG stigma may constitute a novel marker for SQTS in addition to a short QT interval.
Authors: L Zhang; K W Timothy; G M Vincent; M H Lehmann; J Fox; L C Giuli; J Shen; I Splawski; S G Priori; S J Compton; F Yanowitz; J Benhorin; A J Moss; P J Schwartz; J L Robinson; Q Wang; W Zareba; M T Keating; J A Towbin; C Napolitano; A Medina Journal: Circulation Date: 2000-12-05 Impact factor: 29.690
Authors: Ramon Brugada; Kui Hong; Robert Dumaine; Jonathan Cordeiro; Fiorenzo Gaita; Martin Borggrefe; Teresa M Menendez; Josep Brugada; Guido D Pollevick; Christian Wolpert; Elena Burashnikov; Kiyotaka Matsuo; Yue Sheng Wu; Alejandra Guerchicoff; Francesca Bianchi; Carla Giustetto; Rainer Schimpf; Pedro Brugada; Charles Antzelevitch Journal: Circulation Date: 2003-12-15 Impact factor: 29.690
Authors: Chloé Bellocq; Antoni C G van Ginneken; Connie R Bezzina; Mariel Alders; Denis Escande; Marcel M A M Mannens; Isabelle Baró; Arthur A M Wilde Journal: Circulation Date: 2004-05-25 Impact factor: 29.690
Authors: Roberta Pereira; Oscar Campuzano; Georgia Sarquella-Brugada; Sergi Cesar; Anna Iglesias; Josep Brugada; Fernando E S Cruz Filho; Ramon Brugada Journal: Clin Res Cardiol Date: 2017-03-16 Impact factor: 5.460
Authors: Peter J Schwartz; Michael J Ackerman; Charles Antzelevitch; Connie R Bezzina; Martin Borggrefe; Bettina F Cuneo; Arthur A M Wilde Journal: Nat Rev Dis Primers Date: 2020-07-16 Impact factor: 52.329
Authors: David M German; Muammar M Kabir; Thomas A Dewland; Charles A Henrikson; Larisa G Tereshchenko Journal: Ann Noninvasive Electrocardiol Date: 2015-11-02 Impact factor: 1.468
Authors: Oscar Campuzano; Georgia Sarquella-Brugada; Sergi Cesar; Elena Arbelo; Josep Brugada; Ramon Brugada Journal: Front Cardiovasc Med Date: 2018-10-29