Literature DB >> 24589711

Bone's dark side: mutated osteoblasts implicated in leukemia.

Amir Schajnovitz1, David T Scadden1.   

Abstract

Bone-lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies. A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing osteoblastic cells leads to MDS and AML with 100% penetrance and is associated with strikingly similar findings in human patients.

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Year:  2014        PMID： 24589711      PMCID： PMC3975504          DOI： 10.1038/cr.2014.26

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Authors:  Andrew P Weng; Adolfo A Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Journal:  Science       Date:  2004-10-08       Impact factor: 47.728

2.  Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Authors:  Koen Schepers; Eric M Pietras; Damien Reynaud; Johanna Flach; Mikhail Binnewies; Trit Garg; Amy J Wagers; Edward C Hsiao; Emmanuelle Passegué
Journal:  Cell Stem Cell       Date:  2013-07-11       Impact factor: 24.633

3.  A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

Authors:  Carl R Walkley; Gemma Haines Olsen; Sebastian Dworkin; Stewart A Fabb; Jeremy Swann; Grant A McArthur; Susan V Westmoreland; Pierre Chambon; David T Scadden; Louise E Purton
Journal:  Cell       Date:  2007-06-15       Impact factor: 41.582

4.  Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.

Authors:  Colleen Delaney; Shelly Heimfeld; Carolyn Brashem-Stein; Howard Voorhies; Ronald L Manger; Irwin D Bernstein
Journal:  Nat Med       Date:  2010-01-17       Impact factor: 53.440

5.  The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

Authors:  Thomas Mercher; Glen D Raffel; Sandra A Moore; Melanie G Cornejo; Dominique Baudry-Bluteau; Nicolas Cagnard; Jonathan L Jesneck; Yana Pikman; Dana Cullen; Ifor R Williams; Koichi Akashi; Hirokazu Shigematsu; Jean-Pierre Bourquin; Marco Giovannini; William Vainchenker; Ross L Levine; Benjamin H Lee; Olivier A Bernard; D Gary Gilliland
Journal:  J Clin Invest       Date:  2009-03-16       Impact factor: 14.808

6.  Osteoblastic cells regulate the haematopoietic stem cell niche.

Authors:  L M Calvi; G B Adams; K W Weibrecht; J M Weber; D P Olson; M C Knight; R P Martin; E Schipani; P Divieti; F R Bringhurst; L A Milner; H M Kronenberg; D T Scadden
Journal:  Nature       Date:  2003-10-23       Impact factor: 49.962

7.  Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.

Authors:  Carl R Walkley; Jeremy M Shea; Natalie A Sims; Louise E Purton; Stuart H Orkin
Journal:  Cell       Date:  2007-06-15       Impact factor: 41.582

8.  Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

Authors:  Marc H G P Raaijmakers; Siddhartha Mukherjee; Shangqin Guo; Siyi Zhang; Tatsuya Kobayashi; Jesse A Schoonmaker; Benjamin L Ebert; Fatima Al-Shahrour; Robert P Hasserjian; Edward O Scadden; Zinmar Aung; Marc Matza; Matthias Merkenschlager; Charles Lin; Johanna M Rommens; David T Scadden
Journal:  Nature       Date:  2010-03-21       Impact factor: 49.962

9.  Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

Authors:  Camille Lobry; Panagiotis Ntziachristos; Delphine Ndiaye-Lobry; Philmo Oh; Luisa Cimmino; Nan Zhu; Elisa Araldi; Wenhuo Hu; Jacquelyn Freund; Omar Abdel-Wahab; Sherif Ibrahim; Dimitris Skokos; Scott A Armstrong; Ross L Levine; Christopher Y Park; Iannis Aifantis
Journal:  J Exp Med       Date:  2013-01-28       Impact factor: 14.307

10.  Notch activation inhibits AML growth and survival: a potential therapeutic approach.

Authors:  Sankaranarayanan Kannan; Robert M Sutphin; Mandy G Hall; Leonard S Golfman; Wendy Fang; Riitta M Nolo; Lauren J Akers; Richard A Hammitt; John S McMurray; Steven M Kornblau; Ari M Melnick; Maria E Figueroa; Patrick A Zweidler-McKay
Journal:  J Exp Med       Date:  2013-01-28       Impact factor: 14.307
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  3 in total

Review 1.  Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?

Authors:  Lisa Pleyer; Peter Valent; Richard Greil
Journal:  Int J Mol Sci       Date:  2016-06-27       Impact factor: 5.923

Review 2.  Oral manifestations of leukemia as part of early diagnosis.

Authors:  Reyna Aguilar Quispe; Elizabeth Marques Aguiar; Claudia Teresa de Oliveira; Ana Cristina Xavier Neves; Paulo Sérgio da Silva Santos
Journal:  Hematol Transfus Cell Ther       Date:  2021-11-22

Review 3.  Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches.

Authors:  Ander Abarrategi; Syed A Mian; Diana Passaro; Kevin Rouault-Pierre; William Grey; Dominique Bonnet
Journal:  J Exp Med       Date:  2018-02-16       Impact factor: 14.307
  3 in total

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