| Literature DB >> 24589485 |
Maria E S B Barros1, Juliano C R Freitas1, Juliana M Oliveira1, Carlos H B da Cruz1, Paulo B N da Silva2, Larissa C C de Araújo2, Gardenia C G Militão2, Teresinha G da Silva3, Roberta A Oliveira1, Paulo H Menezes4.
Abstract
(-)-Massoialactone, an α,β-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.Entities:
Keywords: Anti-inflammatory activity; Antitumoral activity; Lactones; Massoialactone; Tellurides
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Year: 2014 PMID： 24589485 DOI： 10.1016/j.ejmech.2014.02.013
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514