OBJECTIVE: To review the immune response to anesthesia including mechanical ventilation, inhaled anesthetic gases, and injectable anesthetics and sedatives. STUDY DESIGN: Review. METHODS AND DATABASES: Multiple literature searches were performed using PubMed and Google Scholar from spring 2012 through fall 2013. Relevant anesthetic and immune terms were used to search databases without year published or species constraints. The online database for Veterinary Anaesthesia and Analgesia and the Journal of Veterinary Emergency and Critical Care were searched by issue starting in 2000 for relevant articles. CONCLUSION: Recent research data indicate that commonly used volatile anesthetic agents, such as isoflurane and sevoflurane, may have a protective effect on vital organs. With the lung as the target organ, protection using an appropriate anesthetic protocol may be possible during direct pulmonary insults, including mechanical ventilation, and during systemic disease processes, such as endotoxemia, generalized sepsis, and ischemia-reperfusion injury.
OBJECTIVE: To review the immune response to anesthesia including mechanical ventilation, inhaled anesthetic gases, and injectable anesthetics and sedatives. STUDY DESIGN: Review. METHODS AND DATABASES: Multiple literature searches were performed using PubMed and Google Scholar from spring 2012 through fall 2013. Relevant anesthetic and immune terms were used to search databases without year published or species constraints. The online database for Veterinary Anaesthesia and Analgesia and the Journal of Veterinary Emergency and Critical Care were searched by issue starting in 2000 for relevant articles. CONCLUSION: Recent research data indicate that commonly used volatile anesthetic agents, such as isoflurane and sevoflurane, may have a protective effect on vital organs. With the lung as the target organ, protection using an appropriate anesthetic protocol may be possible during direct pulmonary insults, including mechanical ventilation, and during systemic disease processes, such as endotoxemia, generalized sepsis, and ischemia-reperfusion injury.
Authors: Venkatesh Kundumani-Sridharan; Jaganathan Subramani; Somasundaram Raghavan; Guru P Maiti; Cade Owens; Trevor Walker; John Wasnick; Steven Idell; Kumuda C Das Journal: Am J Physiol Lung Cell Mol Physiol Date: 2019-02-27 Impact factor: 5.464
Authors: Ana Lucía Rodríguez-Perea; Johanna Gutierrez-Vargas; Gloria Patricia Cardona-Gómez; Carlos Julio Montoya Guarin; Mauricio Rojas; Paula Andrea Velilla Hernández Journal: J Neuroimmune Pharmacol Date: 2016-09-10 Impact factor: 4.147