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Literature DB >> 24588594

Ca(2+) release-activated Ca(2+) channel inhibitors.

Paolo Pevarello¹, Silvia Cainarca, Chiara Liberati, Paola Tarroni, Francesco Piscitelli, Elda Severi.

Abstract

Ca(2+) release-activated Ca(2+) (CRAC) channels are becoming important targets for therapeutic intervention in several areas of disease, including immunology, allergy and cancer. In parallel to the progression towards reliable methods for measuring CRAC currents and their inhibition, patents have been generated by several companies. In this Patent Review, an analysis of the patents in the CRAC channel inhibition filed is presented. A discussion of the biological methods used in the patents is included. The general interest in this area is growing fast with almost 80% of the patents issued after 2010.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2014 PMID： 24588594 DOI： 10.4155/ppa.14.7

Source DB: PubMed Journal: Pharm Pat Anal ISSN： 2046-8954

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Cited

8 in total

Review 1. Store-operated CRAC channel inhibitors: opportunities and challenges.

Authors: Chengsen Tian; Lupei Du; Yubin Zhou; Minyong Li
Journal: Future Med Chem Date: 2016-05-05 Impact factor: 3.808

2. Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.

Authors: Sha Bai; Masazumi Nagai; Steffi K Koerner; Aristidis Veves; Lijun Sun
Journal: Bioorg Med Chem Lett Date: 2016-12-27 Impact factor: 2.823

3. Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.

Authors: Hai-zhen Zhang; Xiao-lan Xu; Hua-yan Chen; Sher Ali; Dan Wang; Jun-wei Yu; Tao Xu; Fa-jun Nan
Journal: Acta Pharmacol Sin Date: 2015-08-10 Impact factor: 6.150

Ca(2+) release-activated Ca(2+) channel inhibitors.

Review 1. Store-operated CRAC channel inhibitors: opportunities and challenges.

2. Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.

3. Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.

4. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca²⁺ entry pathway.

5. 1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry.

Review 6. Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases.

Review 7. Calcium Permeable Channels in Cancer Hallmarks.

Review 8. Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis.

Ca(2+) release-activated Ca(2+) channel inhibitors.

Review 1. Store-operated CRAC channel inhibitors: opportunities and challenges.

2. Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.

3. Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.

4. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway.

5. 1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry.

Review 6. Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases.

Review 7. Calcium Permeable Channels in Cancer Hallmarks.

Review 8. Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis.

4. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca²⁺ entry pathway.