Literature DB >> 2458822

Ectopic production of salivary-type amylase by a IgA-lambda-type multiple myeloma.

H Hata1, H Matsuzaki, K Tanaka, H Nomura, T Kagimoto, M Takeya, N Yamane, K Takatsuki.   

Abstract

A patient with IgA-lambda-type multiple myeloma who appeared to be secreting salivary-type amylase ectopically is reported. Both the patient's serum and urine contained high levels of amylase. Amylase activity in the supernatant of cultured myeloma cells, obtained from the patient's pleural effusion while he had malignant pleuritis, increased almost linearly from the time of cell seeding. The presence of IgA and S-type amylase in the myeloma cells was demonstrated cytochemically and by immunoelectron microscopy. These observations showed that amylase was produced by these human myeloma cells.

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Year:  1988        PMID： 2458822     DOI： 10.1002/1097-0142(19881015)62:8<1511::aid-cncr2820620811>3.0.co;2-l

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  3 in total

1.  Immunohistochemical, ultrastructural and biochemical studies of an amylase-producing breast carcinoma.

Authors:  H Inaji; H Koyama; M Higashiyama; S Noguchi; H Yamamoto; O Ishikawa; K Omichi; T Iwanaga; A Wada
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

2.  Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes.

Authors:  K Seyama; T Nukiwa; K Takahashi; H Takahashi; S Kira
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

3.  Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells.

Authors:  Shohei Mizuno; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Tomoko Narita; Masaki Ri; Motonori Mizutani; Mineaki Goto; Mayuko Gotou; Norikazu Tsunekawa; Masato Shikami; Shinsuke Iida; Yoshitaka Hosokawa; Hiroshi Miwa; Ryuzo Ueda; Masakazu Nitta; Akiyoshi Takami
Journal:  Int J Hematol       Date:  2015-09-04       Impact factor: 2.490
  3 in total

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