Rodrigo Chamorro1, Raffaele Ferri2, Cecilia Algarín1, Marcelo Garrido1, Betsy Lozoff3, Patricio Peirano1. 1. Sleep Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. 2. Sleep Research Center, Department of Neurology IC, OASI Research Institute (IRCCS), Troina, Italy. 3. Center for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Abstract
STUDY OBJECTIVES: To compare sleep microstructure (cyclic alternating pattern, CAP) characteristics in otherwise healthy overweight (OW) and normal weight (NW) children. DESIGN: Polysomnographic cross-sectional study. SETTING: Sleep laboratory. PARTICIPANTS: Fifty-eight (26 NW and 32 OW) 10-year-old children. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Participants were part of a longitudinal study beginning in infancy and free of sleep disorders. Groups were based on body-mass index (BMI) z-score. From polysomnographic overnight recordings, sleep-waking states were scored according to international criteria. CAP analysis was performed visually during NREM sleep. Conventional sleep parameters were similar between groups. BMI was positively related to CAP rate and CAP sequences but inversely related to CAP B phase duration. Differences between groups were confined to slow-wave sleep (SWS), with OW children showing higher CAP rate, CAP cycles, and CAP A1 number and index and shorter CAP cycles and B phase duration. They also showed more CAP class intervals shorter than 30 s, and a suggestive trend for fewer intervals longer than 30 s. CONCLUSIONS: Cyclic alternating pattern characteristics in children related to nutritional status and were altered in overweight subjects during slow-wave sleep. We suggest that the more frequent oscillatory pattern of electroencephalographic slow activity in overweight subjects might reflect less stable slow-wave sleep episodes.
STUDY OBJECTIVES: To compare sleep microstructure (cyclic alternating pattern, CAP) characteristics in otherwise healthy overweight (OW) and normal weight (NW) children. DESIGN: Polysomnographic cross-sectional study. SETTING: Sleep laboratory. PARTICIPANTS: Fifty-eight (26 NW and 32 OW) 10-year-old children. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS:Participants were part of a longitudinal study beginning in infancy and free of sleep disorders. Groups were based on body-mass index (BMI) z-score. From polysomnographic overnight recordings, sleep-waking states were scored according to international criteria. CAP analysis was performed visually during NREM sleep. Conventional sleep parameters were similar between groups. BMI was positively related to CAP rate and CAP sequences but inversely related to CAP B phase duration. Differences between groups were confined to slow-wave sleep (SWS), with OW children showing higher CAP rate, CAP cycles, and CAP A1 number and index and shorter CAP cycles and B phase duration. They also showed more CAP class intervals shorter than 30 s, and a suggestive trend for fewer intervals longer than 30 s. CONCLUSIONS: Cyclic alternating pattern characteristics in children related to nutritional status and were altered in overweight subjects during slow-wave sleep. We suggest that the more frequent oscillatory pattern of electroencephalographic slow activity in overweight subjects might reflect less stable slow-wave sleep episodes.
Authors: Natalie D Shaw; Andrew W McHill; Michele Schiavon; Tairmae Kangarloo; Piotr W Mankowski; Claudio Cobelli; Elizabeth B Klerman; Janet E Hall Journal: Sleep Date: 2016-08-01 Impact factor: 5.849