Jeong-Yoon Choi1, Ji-Sun Kim, Ji Hyun Kim, Kyungmi Oh, Seong-Beom Koh, Woo-Keun Seo. 1. From the Department of Neurology (J.-Y.C.), Korea University College of Medicine, Korea University Ansan Hospital, Ansan; Department of Neurology (J.-S.K.), Korea University College of Medicine, Korea University Anam Hospital, Seoul; and Department of Neurology (J.H., K.O., S.-B.K., W.-K.S.), Korea University College of Medicine, Korea University Guro Hospital, Seoul.
Abstract
OBJECTIVE: To determine whether the plasma level of free fatty acid (FFA) could be associated with recurrent stroke in cardioembolic (CE) stroke patients. METHODS: We analyzed data from 669 acute ischemic stroke patients and examined the association between FFA concentration and recurrent stroke in CE stroke patients compared with non-CE stroke patients. RESULTS: The baseline plasma FFA concentration (mEq/L) was approximately 1.5-fold higher in CE stroke patients (1.01 ± 0.63) than in non-CE stroke patients (0.72 ± 0.51). Multivariate logistic analysis showed that an increased level of FFA was significantly associated with CE stroke (hazard ratio [HR] 2.124, confidence interval [CI] 1.492-3.024). During the mean follow-up period of 25.4 months, a total of 56 (8.4%) patients experienced a stroke recurrence. The recurrence rate did not differ between patients with CE (10.5%) and non-CE (8.0%) stroke (p = 0.396). In CE stroke patients, an elevated baseline FFA concentration was independently associated with stroke recurrence (HR 2.711, CI 1.056-6.959). However, there was no association between FFA and stroke recurrence in non-CE stroke patients. CONCLUSION: In this retrospective registry-based observational study, CE stroke seemed to be associated with elevated plasma level of FFA. In addition, the present study suggested that an elevated FFA concentration could be a useful indicator for predicting recurrent stroke in CE stroke patients.
OBJECTIVE: To determine whether the plasma level of free fatty acid (FFA) could be associated with recurrent stroke in cardioembolic (CE) strokepatients. METHODS: We analyzed data from 669 acute ischemic strokepatients and examined the association between FFA concentration and recurrent stroke in CE strokepatients compared with non-CE strokepatients. RESULTS: The baseline plasma FFA concentration (mEq/L) was approximately 1.5-fold higher in CE strokepatients (1.01 ± 0.63) than in non-CE strokepatients (0.72 ± 0.51). Multivariate logistic analysis showed that an increased level of FFA was significantly associated with CE stroke (hazard ratio [HR] 2.124, confidence interval [CI] 1.492-3.024). During the mean follow-up period of 25.4 months, a total of 56 (8.4%) patients experienced a stroke recurrence. The recurrence rate did not differ between patients with CE (10.5%) and non-CE (8.0%) stroke (p = 0.396). In CE strokepatients, an elevated baseline FFA concentration was independently associated with stroke recurrence (HR 2.711, CI 1.056-6.959). However, there was no association between FFA and stroke recurrence in non-CE strokepatients. CONCLUSION: In this retrospective registry-based observational study, CE stroke seemed to be associated with elevated plasma level of FFA. In addition, the present study suggested that an elevated FFA concentration could be a useful indicator for predicting recurrent stroke in CE strokepatients.