OBJECTIVES: To determine whether obesity concurrent with sarcopenia (low muscle mass) or dynapenia (low muscle strength) is associated with increased falls risk in middle-aged and older adults. METHODS: 5-year prospective cohort study including 674 community-dwelling volunteers (mean ± SD age 61.4 ± 7.0 years; 48% female). Sarcopenia and dynapenia were defined as lowest sex-specific tertiles for dual-energy X-ray (DXA)-assessed appendicular lean mass (adjusted for height and fat mass) or lower-limb strength, respectively. Obesity was defined as the highest tertiles of DXA-assessed total or trunk fat mass. Change in falls risk was calculated using the Physiological Profile Assessment (z-scores: 0-1 = mild increased risk; 1-2 = moderate increased risk; >2 = marked increased risk). RESULTS: Multivariable linear regression analyses revealed mild but significantly increased falls risk scores for dynapenic obesity (change in mean z-score compared to non-dynapenic, non-obese group: 0.33, 95% CI 0.06-0.59 [men] and 0.46, 95% CI 0.21-0.72 [women]) and dynapenia (0.25, 95% CI 0.05-0.46 [women only]). CONCLUSIONS: Dynapenic obesity, but not sarcopenic obesity, is predictive of increased falls risk score in middle-aged and older adults. In clinical settings, muscle function assessments may be useful for predicting falls risk in obese patients.
OBJECTIVES: To determine whether obesity concurrent with sarcopenia (low muscle mass) or dynapenia (low muscle strength) is associated with increased falls risk in middle-aged and older adults. METHODS: 5-year prospective cohort study including 674 community-dwelling volunteers (mean ± SD age 61.4 ± 7.0 years; 48% female). Sarcopenia and dynapenia were defined as lowest sex-specific tertiles for dual-energy X-ray (DXA)-assessed appendicular lean mass (adjusted for height and fat mass) or lower-limb strength, respectively. Obesity was defined as the highest tertiles of DXA-assessed total or trunk fat mass. Change in falls risk was calculated using the Physiological Profile Assessment (z-scores: 0-1 = mild increased risk; 1-2 = moderate increased risk; >2 = marked increased risk). RESULTS: Multivariable linear regression analyses revealed mild but significantly increased falls risk scores for dynapenic obesity (change in mean z-score compared to non-dynapenic, non-obese group: 0.33, 95% CI 0.06-0.59 [men] and 0.46, 95% CI 0.21-0.72 [women]) and dynapenia (0.25, 95% CI 0.05-0.46 [women only]). CONCLUSIONS:Dynapenic obesity, but not sarcopenic obesity, is predictive of increased falls risk score in middle-aged and older adults. In clinical settings, muscle function assessments may be useful for predicting falls risk in obesepatients.
Authors: J C Menant; F Weber; J Lo; D L Sturnieks; J C Close; P S Sachdev; H Brodaty; S R Lord Journal: Osteoporos Int Date: 2016-07-09 Impact factor: 4.507
Authors: Shawna Follis; Alan Cook; Jennifer W Bea; Scott B Going; Deepika Laddu; Jane A Cauley; Aladdin H Shadyab; Marcia L Stefanick; Zhao Chen Journal: J Am Geriatr Soc Date: 2018-10-30 Impact factor: 5.562
Authors: Andrea P Rossi; Lara Bianchi; Stefano Volpato; Stefania Bandinelli; Jack Guralnik; Mauro Zamboni; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2017-08-01 Impact factor: 6.053
Authors: Marshall G Miller; Kathryn N Porter Starr; Jamie Rincker; Melissa C Orenduff; Shelley R McDonald; Carl F Pieper; Angela R Fruik; Kenneth W Lyles; Connie W Bales Journal: J Nutr Gerontol Geriatr Date: 2021-03-13