Literature DB >> 24584132

A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters.

Wenbin Qi1, Jingwei Li, J A Cowan.   

Abstract

Glutathione-complexed [2Fe-2S] cluster is shown to significantly stimulate the ATPase activity of an ABCB7-type transporter in both solution and proteoliposome-bound forms (KD ∼ 68 μM). The cluster is a likely natural substrate for this transporter, which has been implicated in cytosolic Fe-S cluster protein maturation. A possible substrate-binding site is identified on a new structural model for the active transporter.

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Year:  2014        PMID： 24584132      PMCID： PMC4052440          DOI： 10.1039/c3cc48239a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds.

Authors:  Grit Kuhnke; Karina Neumann; Ulrich Mühlenhoff; Roland Lill
Journal:  Mol Membr Biol       Date:  2006 Mar-Apr       Impact factor: 2.857

2.  Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation.

Authors:  S Bekri; G Kispal; H Lange; E Fitzsimons; J Tolmie; R Lill; D F Bishop
Journal:  Blood       Date:  2000-11-01       Impact factor: 22.113

3.  The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.

Authors:  G Kispal; P Csere; C Prohl; R Lill
Journal:  EMBO J       Date:  1999-07-15       Impact factor: 11.598

4.  Maturation of cytosolic iron-sulfur proteins requires glutathione.

Authors:  Katalin Sipos; Heike Lange; Zsuzsanna Fekete; Pascaline Ullmann; Roland Lill; Gyula Kispal
Journal:  J Biol Chem       Date:  2002-05-14       Impact factor: 5.157

5.  The yeast a-factor transporter Ste6p, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export.

Authors:  C J Ketchum; W K Schmidt; G V Rajendrakumar; S Michaelis; P C Maloney
Journal:  J Biol Chem       Date:  2001-06-01       Impact factor: 5.157

6.  The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.

Authors:  Janneke Balk; Daili J Aguilar Netz; Katharina Tepper; Antonio J Pierik; Roland Lill
Journal:  Mol Cell Biol       Date:  2005-12       Impact factor: 4.272

7.  The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins.

Authors:  Jana Gerber; Karina Neumann; Corinna Prohl; Ulrich Mühlenhoff; Roland Lill
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

Review 8.  Iron-sulfur cluster biosynthesis: toward an understanding of cellular machinery and molecular mechanism.

Authors:  Sheref S Mansy; J A Cowan
Journal:  Acc Chem Res       Date:  2004-09       Impact factor: 22.384

9.  Glutathione-complexed iron-sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability.

Authors:  Wenbin Qi; Jingwei Li; C Y Chain; G A Pasquevich; A F Pasquevich; J A Cowan
Journal:  Chem Commun (Camb)       Date:  2013-07-18       Impact factor: 6.222

10.  The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

Authors:  Corinne Pondarré; Brendan B Antiochos; Dean R Campagna; Stephen L Clarke; Eric L Greer; Kathryn M Deck; Alice McDonald; An-Ping Han; Amy Medlock; Jeffery L Kutok; Sheila A Anderson; Richard S Eisenstein; Mark D Fleming
Journal:  Hum Mol Genet       Date:  2006-02-08       Impact factor: 6.150
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  22 in total

1.  Reconstitution, characterization, and [2Fe-2S] cluster exchange reactivity of a holo human BOLA3 homodimer.

Authors:  Christine Wachnowsky; Brian Rao; Sambuddha Sen; Brian Fries; Cecil J Howard; Jennifer J Ottesen; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2019-09-05       Impact factor: 3.358

2.  Glutathione-coordinated [2Fe-2S] cluster is stabilized by intramolecular salt bridges.

Authors:  Jingwei Li; Stephen A Pearson; Kevin D Fenk; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2015-10-14       Impact factor: 3.358

3.  Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1.

Authors:  Nathaniel A Wesley; Christine Wachnowsky; Insiya Fidai; J A Cowan
Journal:  FEBS J       Date:  2017-10-12       Impact factor: 5.542

4.  Role of protein-glutathione contacts in defining glutaredoxin-3 [2Fe-2S] cluster chirality, ligand exchange and transfer chemistry.

Authors:  Sambuddha Sen; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2017-08-23       Impact factor: 3.358

5.  Glutathione-coordinated [2Fe-2S] cluster: a viable physiological substrate for mitochondrial ABCB7 transport.

Authors:  Jingwei Li; J A Cowan
Journal:  Chem Commun (Camb)       Date:  2015-02-11       Impact factor: 6.222

Review 6.  Mammalian iron-sulphur proteins: novel insights into biogenesis and function.

Authors:  Tracey A Rouault
Journal:  Nat Rev Mol Cell Biol       Date:  2014-11-26       Impact factor: 94.444

7.  The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1.

Authors:  Ioana Ferecatu; Sergio Gonçalves; Marie-Pierre Golinelli-Cohen; Martin Clémancey; Alain Martelli; Sylvie Riquier; Eric Guittet; Jean-Marc Latour; Hélène Puccio; Jean-Claude Drapier; Ewen Lescop; Cécile Bouton
Journal:  J Biol Chem       Date:  2014-07-10       Impact factor: 5.157

Review 8.  Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.

Authors:  Nunziata Maio; Tracey A Rouault
Journal:  Biochim Biophys Acta       Date:  2014-09-19

9.  Defining the mechanism of the mitochondrial Atm1p [2Fe-2S] cluster exporter.

Authors:  Stephen A Pearson; Christine Wachnowsky; J A Cowan
Journal:  Metallomics       Date:  2020-06-24       Impact factor: 4.526

Review 10.  Cellular sensing and transport of metal ions: implications in micronutrient homeostasis.

Authors:  Amanda J Bird
Journal:  J Nutr Biochem       Date:  2015-08-07       Impact factor: 6.048
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